GCLM
Gene Information
- Official Symbol: GCLM
- Official Name: glutamate-cysteine ligase modifier subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 2730
- UniProt: P48507
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Aldo ket red |
GO Terms
| positive regulation of glutamate-cysteine ligase activity |
| regulation of glutamate-cysteine ligase activity |
| glutamate-cysteine ligase catalytic subunit binding |
| cellular response to L-phenylalanine derivative |
| glutamate-cysteine ligase activity |
| hepatic stellate cell activation |
| glutamate-cysteine ligase complex |
| cellular response to thyroxine stimulus |
| response to human chorionic gonadotropin |
| response to L-phenylalanine derivative |
| response to thyroxine |
| fibroblast activation |
| positive regulation of ligase activity |
| response to nitrosative stress |
| regulation of ligase activity |
| cysteine metabolic process |
| cellular response to follicle-stimulating hormone stimulus |
| glutathione biosynthetic process |
| cellular response to thyroid hormone stimulus |
| cellular response to hepatocyte growth factor stimulus |
| enzyme regulator activity |
| response to follicle-stimulating hormone |
| nonribosomal peptide biosynthetic process |
| response to hepatocyte growth factor |
| cellular response to gonadotropin stimulus |
| regulation of mitochondrial depolarization |
| response to thyroid hormone |
| response to gonadotropin |
| glutamate metabolic process |
| sulfur amino acid metabolic process |
| serine family amino acid metabolic process |
| regulation of membrane depolarization |
| cellular modified amino acid biosynthetic process |
| glutathione metabolic process |
| apoptotic mitochondrial changes |
| response to activity |
| cellular response to glucose stimulus |
| cellular response to amino acid stimulus |
| regulation of mitochondrial membrane potential |
| glutamine family amino acid metabolic process |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| cellular response to carbohydrate stimulus |
| cellular glucose homeostasis |
| dicarboxylic acid metabolic process |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| negative regulation of extrinsic apoptotic signaling pathway |
| cellular response to fibroblast growth factor stimulus |
| response to amino acid |
| response to fibroblast growth factor |
| response to glucose |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| response to hexose |
| negative regulation of neuron apoptotic process |
| response to monosaccharide |
| regulation of extrinsic apoptotic signaling pathway |
| vascular process in circulatory system |
| response to carbohydrate |
| sulfur compound biosynthetic process |
| glucose homeostasis |
| carbohydrate homeostasis |
| cellular modified amino acid metabolic process |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| cellular response to acid chemical |
| alpha-amino acid metabolic process |
| cofactor biosynthetic process |
| response to nutrient |
| negative regulation of apoptotic signaling pathway |
| aging |
| cellular amino acid metabolic process |
| regulation of neuron death |
| response to acid chemical |
| sulfur compound metabolic process |
| response to oxidative stress |
| blood circulation |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| peptide biosynthetic process |
| regulation of membrane potential |
| cofactor metabolic process |
| mitochondrion organization |
| protein heterodimerization activity |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| regulation of anatomical structure size |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| response to growth factor |
| cellular response to organic cyclic compound |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| cellular chemical homeostasis |
| ion homeostasis |
| cellular amide metabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| apoptotic process |
| negative regulation of cell death |
| response to organonitrogen compound |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| response to drug |
| organic acid metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| cell death |
| response to cytokine |
| chemical homeostasis |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| regulation of cell death |
| small molecule metabolic process |
| positive regulation of molecular function |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4927
- Expression level (log2 read counts): 4.89
Expression Distribution
GCLM Expression in NALM6 Cells: 4.89
