KCMF1

Entrez Summary: N/A
UniProt Summary: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269|PubMed:15581609}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.77
Ethanol 0.01 R05 exp234	-2.35
Olaparib 4μM R08 exp512	-2.33
Bortezomib 0.005μM R00 exp6	-2.23
ML-792 0.2μM R08 exp505	-2.22
FK-506 30μM R07 exp359	-2.03
Latrunculin-B 10μM R07 exp374	-2.01
Vemurafenib 6.6μM R02 exp89	-1.97
ZLN024 50μM R08 exp538	-1.96
Citral 50μM R06 exp274	-1.91
Vemurafenib 6.6μM R08 exp434	-1.9
Doxycycline 10μM R00 exp18	-1.86
Rapamycin 10μM R00 exp30	-1.83
Wortmannin 0.5μM R00 exp37	-1.8
Amiloride 100μM R08 exp447	-1.78
Thimerosal 0.85μM R08 exp529	-1.76
Geldanamycin 0.01μM R05 exp235	-1.74
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.72
B02 10μM R08 exp453	-1.7
Arsenate 40μM R06 exp264	1.91
GSK461364A 0.005μM R03 exp125	1.96
Actinomycin-D 0.01μM R00 exp4	2.28
MLN-4924 2μM R00 exp22	2.56
BI-2536 0.0042μM R03 exp95	3
BI-6727 0.0125μM R03 exp97	3.05
42°C R08 exp539	3.57

Global Fraction of Cell Lines Where Essential: 278/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	8/28
blood	8/28
bone	4/26
breast	18/33
central nervous system	22/56
cervix	0/4
colorectal	8/17
esophagus	9/13
fibroblast	0/1
gastric	9/16
kidney	5/21
liver	7/20
lung	34/75
lymphocyte	6/16
ovary	6/26
pancreas	11/24
peripheral nervous system	2/16
plasma cell	4/15
prostate	0/1
skin	11/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	10/29
uterus	0/5

Expression Distribution