PTAR1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethambutol 25μM R08 exp481	-2.93
Apcin 25μM plus proTAME 2μM R04 exp177	-2.52
Bafilomycin-A1 0.009μM R08 exp454	-2.48
WNT3A 44ng/ml R08 exp537	-2.27
BH1 1μM R04 exp169	-2.22
IU1-47 25μM R04 exp182	-2.17
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.09
UM0011500 5μM R05 exp245	-2
UNC2400 2μM R03 exp156	-2
Dihydrosphingosine 8μM R08 exp476	-1.87
Ribavirin 10 to 15μM on day4 R04 exp160	-1.82
Vemurafenib 6.6μM R08 exp434	-1.81
Losmapimod 1μM R07 exp376	-1.79
D-Fructose 10000μM R06 exp279	-1.76
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.75
Demecolcine 0.03μM R05 exp228	-1.73
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.72
Clomiphene 4.4μM R02 exp68	-1.72
ONC212 0.15μM R08 exp513	1.73
GSK-J4 1.5μM R08 exp441	1.75
GSK626616 14μM R08 exp485	1.77
Erlotinib 10μM R05 exp216	1.78
HMS-I2 10μM R06 exp288	1.79
Docetaxel 0.002μM R01 exp45	1.82
Mubritinib 0.2μM R01 exp48	1.92
Dorsomorphin 5μM R07 exp357	1.97
Rapamycin 10μM R00 exp30	2.07
Bisphenol A 100μM R06 exp269	2.08
2-Deoxy-D-glucose 800μM R05 exp214	2.11
TIC10 10μM R08 exp532	2.22
Milciclib 2μM R08 exp502	2.29
Amiloride 100μM R08 exp447	2.46
ZLN024 50μM R08 exp538	2.77
Cannabidiol 13μM R08 exp465	2.98
∆-9-Tetrahydrocannabinol 30μM R08 exp445	3.34
UM0129480 7μM R02 exp85	3.73

Global Fraction of Cell Lines Where Essential: 21/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	1/20
lung	6/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution