RNF113A

Gene Information

Official Symbol: RNF113A
Official Name: ring finger protein 113A
Aliases and Previous Symbols: N/A
Entrez ID: 7737
UniProt: O15541
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-2.61
Atovaquone 15μM R08 exp451	-2.43
Etoposide 1μM R00 exp19	-2.4
Deferoxamine 11μM R07 exp350	-1.96
UM131593 0.2μM R03 exp106	-1.83
TNF-alpha 44ng/ml R08 exp533	1.71
Alda-1 10μM R06 exp262	1.77
MK2206 4μM R08 exp504	1.83
Metformin 40μM R03 exp132	1.88
NFN1 0.1μM R01 exp49	1.95
Selumetinib 20μM R02 exp81	2.01
PNU96415E 10μM R03 exp145	2.04
L-BMAA 500 to 750μM on day4 R04 exp185	2.11
EPZ-5676 30μM R05 exp233	2.19
UNC1999 2μM R03 exp155	2.24

Gene	Correlation
ZNF148	0.51
TCEB3C	0.5
RBM39	0.494
INTS5	0.494
PSMB4	0.485
RPS2	0.484
TCEB3CL2	0.481
RPL35	0.479
SLC6A17	0.477
TCEB3CL	0.475
PRIM1	0.47
HGC6.3	0.47
CACTIN	0.469
MYO1H	0.465
PSMA6	0.463
SART1	0.46
NARFL	0.45
TICRR	0.446
DDTL	0.446
GOLGA8O	0.445
CEP192	0.444
ISCU	0.444
SF3A3	0.439
SNIP1	0.436
CHD4	0.436
GOLGA6L3	0.432
RPS3A	0.431
EIF3G	0.431
ZFAND5	0.429
PSMD14	0.428
DTL	0.427
TBC1D3H	0.426
COPG1	0.425
RPS12	0.424
ORC1	0.424
TP53TG3D	0.424
CDC73	0.423
KCTD17	0.423
WDR75	0.422
SF3A1	0.421
TP53TG3B	0.421
TP53TG3C	0.421
ATP6V1C1	0.42
PSMD1	0.42
TP53TG3	0.42
DHX38	0.42
TWISTNB	0.419
RPA2	0.418
RRP15	0.417
CCDC94	0.417
ATP6V0B	0.416
DIDO1	0.416
EXD1	0.415
PSMB2	0.415
C14orf93	0.414
SETD1A	0.413
BYSL	0.412
ORC6	0.412
CDC6	0.411
POLA2	0.41
AKIRIN2	0.41
AQR	0.409
VASN	0.409
RPL34	0.407
INTS6	0.407
RRP7A	0.406
COPA	0.404
CCNA2	0.404
KIAA0947	0.403
DAND5	0.403
LRR1	0.403
MDM2	0.402
APC2	0.402
EIF4A3	0.402
NOL10	0.401
WDR87	0.401
NBPF10	0.4
RBBP5	0.4

Global Fraction of Cell Lines Where Essential: 535/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	23/26
bone	20/26
breast	24/30
central nervous system	36/49
cervix	1/4
colorectal	13/17
esophagus	7/11
fibroblast	0/1
gastric	13/14
kidney	12/18
liver	11/19
lung	52/72
lymphocyte	15/16
ovary	20/25
pancreas	14/22
peripheral nervous system	11/15
plasma cell	7/12
prostate	1/1
skin	16/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	14/22
urinary tract	24/28
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 1613
Expression level (log2 read counts): 4.37

Expression Distribution