Table of Contents

Menadione 5μM R06 exp292

Mechanism of Action

Synthetic analog of vitamin K, quinone redox cycle generates ROS

Technical Notes

Compound References

  • PubChem Name: Menadione
  • Synonyms: Vitamin K3
  • CAS #: 58-27-5
  • PubChem CID: 4055
  • IUPAC: 2-methylnaphthalene-1,4-dione
  • INCHI Name: InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
  • INCHI Key: MJVAVZPDRWSRRC-UHFFFAOYSA-N
  • Molecular Weight: 172.18
  • Canonical SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O
  • Isomeric SMILES: N/A
  • Molecular Formula: C11H8O2

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: M5625
  • Lot #: N/A

Compound Characterization

  • LCMS: Tr 1.21 min, m/z invisible, Lamdba max 250, 262, 336 nm

Dose Response Curve

  • Platform ID: Menadione
  • Min: -21.7794; Max: 99.2492





IC Concentration (µM)
IC10 N/A
IC20 8.0620
IC30 8.3166
IC40 8.5312
IC50 8.7331
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
11/2ScoresViewViewViewViewView