Table of Contents

Thioridazine 5μM R08 exp530

Mechanism of Action

DRD2/4 selectivity, causes cardiac arrhythmia, also has antibiotic activity against M. tuberculosis

Technical Notes

Compound References

  • PubChem Name: Thioridazine hydrochloride
  • Synonyms: N/A
  • CAS #: 130-61-0
  • PubChem CID: 66062
  • IUPAC: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
  • INCHI Name: InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
  • INCHI Key: NZFNXWQNBYZDAQ-UHFFFAOYSA-N
  • Molecular Weight: 407
  • Canonical SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
  • Isomeric SMILES: N/A
  • Molecular Formula: C21H27ClN2S2

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: T9025
  • Lot #: BCBV1701

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H26N2S2 371.16102; found 371.16222

Dose Response Curve

  • Platform ID: Thioridazine
  • Min: -11.3787; Max: 99.9166





IC Concentration (µM)
IC10 4.4700
IC20 5.0190
IC30 5.4210
IC40 5.7740
IC50 6.1180
IC60 6.4830
IC70 6.9050
IC80 7.4580
IC90 8.3730


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
16/1ScoresViewViewViewViewView