ATP6V0B
Gene Information
- Official Symbol: ATP6V0B
- Official Name: ATPase H+ transporting V0 subunit b
- Aliases and Previous Symbols: N/A
- Entrez ID: 533
- UniProt: Q99437
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Pfam Domains GO Terms
Pfam Domains
| ATP-synt C |
GO Terms
| proton-transporting V-type ATPase, V0 domain |
| proton-transporting ATPase activity, rotational mechanism |
| vacuolar membrane |
| phagosome acidification |
| transferrin transport |
| transporter activity |
| phagosome maturation |
| intracellular pH reduction |
| pH reduction |
| iron ion transport |
| phagocytic vesicle membrane |
| regulation of intracellular pH |
| insulin receptor signaling pathway |
| regulation of cellular pH |
| regulation of pH |
| cellular monovalent inorganic cation homeostasis |
| transition metal ion transport |
| monovalent inorganic cation homeostasis |
| proton transmembrane transport |
| cellular response to insulin stimulus |
| regulation of macroautophagy |
| endosome membrane |
| response to insulin |
| cellular response to peptide hormone stimulus |
| cellular response to peptide |
| regulation of autophagy |
| response to peptide hormone |
| monovalent inorganic cation transport |
| response to peptide |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| inorganic cation transmembrane transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| regulation of cellular catabolic process |
| cellular homeostasis |
| response to hormone |
| ion transmembrane transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| protein transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.648 |
| ATP6V1A | 0.531 |
| POLR2J3 | 0.521 |
| UPF1 | 0.5 |
| PSMB2 | 0.493 |
| PSMB4 | 0.484 |
| COPG1 | 0.482 |
| COPE | 0.466 |
| EXOSC5 | 0.463 |
| SUPT6H | 0.461 |
| UTP3 | 0.46 |
| ATP6V1C1 | 0.46 |
| RBBP5 | 0.455 |
| TBC1D3C | 0.454 |
| POLA1 | 0.453 |
| WDR75 | 0.452 |
| SUPT5H | 0.451 |
| RRP7A | 0.449 |
| TBC1D3H | 0.447 |
| SLC6A17 | 0.443 |
| IK | 0.441 |
| SLC4A1 | 0.439 |
| TCEB3CL2 | 0.438 |
| XAB2 | 0.438 |
| VPS52 | 0.436 |
| TUBA8 | 0.436 |
| TP53TG3B | 0.434 |
| TP53TG3C | 0.433 |
| RPL35 | 0.433 |
| TP53TG3 | 0.433 |
| TBC1D3G | 0.432 |
| C14orf93 | 0.43 |
| TCEB3C | 0.43 |
| COPB1 | 0.429 |
| PSMA6 | 0.429 |
| TCEB3CL | 0.427 |
| CHMP4B | 0.427 |
| TICRR | 0.425 |
| CHD4 | 0.424 |
| PSMC2 | 0.424 |
| ZNF655 | 0.422 |
| NBPF10 | 0.422 |
| GAR1 | 0.421 |
| RANBP2 | 0.421 |
| ATP6V0C | 0.418 |
| MED17 | 0.418 |
| CDC45 | 0.416 |
| RNF113A | 0.416 |
| RPS2 | 0.413 |
| OSBP | 0.413 |
| ATP6AP1 | 0.413 |
| NUP160 | 0.412 |
| ATP6V1B2 | 0.409 |
| KCTD17 | 0.408 |
| DDTL | 0.406 |
| ATP6V0A2 | 0.402 |
| SH3BP1 | 0.401 |
| COPB2 | 0.4 |
| PCF11 | 0.4 |
| CTAGE4 | 0.4 |
| TWISTNB | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 733/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/26 |
| breast | 33/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 1/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 362
- Expression level (log2 read counts): 6.37
Expression Distribution
ATP6V0B Expression in NALM6 Cells: 6.37
