NXT1

Entrez Summary: N/A
UniProt Summary: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04μM R07 exp418	-1.87
Selumetinib 20μM R02 exp81	1.81
Actinomycin-D 0.01μM R00 exp4	1.83
AICAR 240μM R05 exp211	1.83
Etoposide 0.3μM R05 exp199	1.93
CI-1040 9.5μM R08 exp472	1.98
Aphidicolin 0.4μM R08 exp440	2.01
RO-3307 4.7μM R02 exp80	2.1
Pimelic-diphenylamide-106 5μM R00 exp28	2.12
Diepoxybutane 3μM R07 exp354	2.28
Benzoate 20000μM R08 exp456	2.48
MLN-4924 2μM R00 exp22	2.53
Mitomycin-C 0.06μM R08 exp503	2.77
5-Fluorouracil 20μM R00 exp2	3.03
Etoposide 1μM R00 exp19	3.03
Rotenone 20μM R00 exp34	4.12
Actinomycin-D 0.001μM R00 exp3	5.41

Global Fraction of Cell Lines Where Essential: 94/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	1/28
bone	1/26
breast	4/33
central nervous system	8/56
cervix	0/4
colorectal	4/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	4/20
lung	8/75
lymphocyte	2/16
ovary	2/26
pancreas	6/24
peripheral nervous system	8/16
plasma cell	1/15
prostate	1/1
skin	1/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution