Table of Contents

LLY-283 2.6μM R06 exp290

Mechanism of Action

Inhibits protein arginine methyltransferase PRMT5, inactive control is LLY-284

Technical Notes

Protein References

  • PubChem Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
  • Synonyms: N/A
  • CAS #: 2040291-27-6
  • PubChem CID: 122669401
  • IUPAC: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
  • INCHI Name: InChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8,11-14,17,22-24H,(H2,18,19,20)/t11-,12+,13-,14-,17-/m1/s1
  • INCHI Key: WWOOWAHTEXIWBO-QFRSUPTLSA-N
  • Molecular Weight: 342.35
  • Canonical SMILES: C1=CC=C(C=C1)C(C2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O)O
  • Isomeric SMILES: C1=CC=C(C=C1)[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O
  • Molecular Formula: C17H18N4O4

Protein Supplier

  • Supplier Name: Structural Genomics Consortium
  • Catalog #: N/A
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H18N4O4 343.14008; found 343.14031

Dose Response Curve

  • Platform ID: LLY-283
  • Min: -21.8158; Max: -5.0973





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
16/5ScoresViewViewViewViewView