COQ4

Entrez Summary: This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. {ECO:0000255|HAMAP- Rule:MF_03111, ECO:0000269|PubMed:18474229}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.78
Hydroxyurea 100μM R07 exp329	1.7
Rapamycin 2μM R07 exp306	1.77
Mitomycin-C 0.06μM R08 exp503	1.82
CFI-400945 25μM R08 exp469	1.96
CR131-b 0.005μM R08 exp474	2.01
Ribavirin 10 to 15μM on day4 R04 exp160	2.27
Ammonium tetrathiomolybdate 10μM R08 exp448	3.31

Global Fraction of Cell Lines Where Essential: 103/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	9/28
bone	3/26
breast	6/33
central nervous system	5/56
cervix	2/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	5/16
kidney	3/21
liver	3/20
lung	13/75
lymphocyte	3/16
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	0/5

Expression Distribution

extrinsic component of mitochondrial inner membrane
quinone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
quinone metabolic process
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
coenzyme biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
cofactor metabolic process
small molecule biosynthetic process
protein-containing complex
mitochondrion
small molecule metabolic process