KLF16
Gene Information
- Official Symbol: KLF16
- Official Name: Kruppel like factor 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 83855
- UniProt: Q9BXK1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| dopamine receptor signaling pathway |
| cellular response to dopamine |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| cellular response to catecholamine stimulus |
| cellular response to monoamine stimulus |
| response to monoamine |
| response to catecholamine |
| cellular response to ammonium ion |
| response to ammonium ion |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cellular response to drug |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cellular response to organic cyclic compound |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| negative regulation of transcription by RNA polymerase II |
| response to organic cyclic compound |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5649
- Expression level (log2 read counts): 5.86
Expression Distribution
KLF16 Expression in NALM6 Cells: 5.86
