GSK591 2.6μM R03 exp128
Mechanism of Action
Inhibits protein arginine methyltransferase PRMT5, inactive control is SGC2096
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide
- Synonyms: EPZ015866; GSK3203591
- CAS #: 1616391-87-7
- PubChem CID: 117072552
- IUPAC: 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide
- INCHI Name: InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
- INCHI Key: TWKYXZSXXXKKJU-FQEVSTJZSA-N
- Molecular Weight: 380.5
- Canonical SMILES: C1CC(C1)NC2=NC=CC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O
- Isomeric SMILES: C1CC(C1)NC2=NC=CC(=C2)C(=O)NC[C@@H](CN3CCC4=CC=CC=C4C3)O
- Molecular Formula: C22H28N4O2
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H28N4O2 381.2285; found 381.22927
Dose Response Curve
- Platform ID: GSK591
- Min: 5.5317; Max: 37.8129
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.1740 |
| IC30 | 3.3135 |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 2.6µM
- Days of incubation: 8
- Doublings: 4.8
- Numbers of reads: 13320156
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 4/2 | Scores |
GSK591 2.6μM R03 exp128
GSK591 2.6μM R03 exp128 vs LLY-283 2.6μM R06 exp290
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs GSK591 2.6μM R03 exp128
