Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Mechanism of Action
Inhibits microtubule depolymerization, semi-synthetic analog of epothilone
- Class / Subclass 1: Cell Cycle / Microtubule Poison
- Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor
Technical Notes
Compound References
- PubChem Name: Ixabepilone
- Synonyms: Azaepothilone B; BMS 247550; BMS 247550-1
- CAS #: 219989-84-1
- PubChem CID: 6445540
- IUPAC: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
- INCHI Name: InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
- INCHI Key: FABUFPQFXZVHFB-PVYNADRNSA-N
- Molecular Weight: 506.7
- Canonical SMILES: CC1CCCC2(C(O2)CC(NC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
- Isomeric SMILES: C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
- Molecular Formula: C27H42N2O5S
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: I941990
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C27H42N2O5S 507.28872; found 507.28672
Dose Response Curve
- Platform ID: Ixabepilone
- Min: -4.1980; Max: 87.9090
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0030 |
| IC30 | 0.0036 |
| IC40 | 0.0043 |
| IC50 | 0.0050 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 04
- Dose: 0.004-0.005µM
- Days of incubation: 8
- Doublings: 6.1
- Numbers of reads: 21290000
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 35/7 | Scores |
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Taxol 0.004μM R03 exp103
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Vincristine 0.0005μM R04 exp190
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Quercetin 20μM R08 exp517
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Mdivi-1 15μM R05 exp217
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs S-trityl-L-cysteine 0.5μM R05 exp243
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs UMK57 1μM R01 exp59
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Vinblastine 0.002μM R01 exp60
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs UMK57 0.6μM R03 exp107
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Sulforaphane 9μM R08 exp526 no dilution day6
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Taxol 0.002μM R01 exp54
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Sulforaphane 9μM R08 exp525
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs proTAME 5μM R04 exp187
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 vs Talazoparib 0.006μM R06 exp299
Epothilone-B 0.0015μM R05 exp231 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Cabazitaxel 0.001μM R05 exp223 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Docetaxel 0.001 to 0.002μM on day4 R04 exp159 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
BML-284 0.09μM R08 exp460 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Docetaxel 0.002μM R01 exp45 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Demecolcine 0.03μM R05 exp228 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
2-Methoxyestradiol 0.55μM R07 exp310 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Colchicine 0.009μM R05 exp215 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
BI-D1870 2μM R04 exp162 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
HMS-I1 1μM R01 exp46 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Alpha-Amanitin 0.5μM R00 exp5 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Genistein 15μM R07 exp360 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
