LB-100 2μM R05 exp210
Mechanism of Action
Inhibits protein phosphatase 2A
- Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor
Technical Notes
Compound References
- PubChem Name: LB-100
- Synonyms: N/A
- CAS #: 1026680-07-8
- PubChem CID: 3578572
- IUPAC: 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
- INCHI Name: InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H,2-7H2,1H3,(H,17,18)
- INCHI Key: JUQMLSGOTNKJKI-UHFFFAOYSA-N
- Molecular Weight: 268.31
- Canonical SMILES: CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3
- Isomeric SMILES: N/A
- Molecular Formula: C13H20N2O4
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S7537
- Lot #: N/A
Compound Characterization
- LCMS: Tr 0.14 min, m/z 269+ [M+H]+, 267- [M-H]-
Dose Response Curve
- Platform ID: LB-100
- Min: -10.4657; Max: 88.4509
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 3.7707 |
| IC30 | 4.7035 |
| IC40 | 5.6380 |
| IC50 | 6.6580 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 2µM
- Days of incubation: 8
- Doublings: 4.4
- Numbers of reads: 20938108
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 7/28 | Scores |
LB-100 2μM R05 exp210
LB-100 2μM R05 exp210 vs LB-100 4.1μM R02 exp72
LB-100 2μM R05 exp210 vs Pyridostatin 4μM R05 exp240
LB-100 2μM R05 exp210 vs Vincristine 0.0005μM R04 exp190
Erlotinib 10μM R05 exp216 vs LB-100 2μM R05 exp210
Ethanol 0.01 R05 exp234 vs LB-100 2μM R05 exp210
GSK626616 14μM R08 exp485 vs LB-100 2μM R05 exp210
