ARFRP1

Gene Information

Official Symbol: ARFRP1
Official Name: ADP ribosylation factor related protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 10139
UniProt: Q13795
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. {ECO:0000250|UniProtKB:Q8BXL7}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-3.29
Tubacin 1.6μM R07 exp416	-2.68
Cryptotanshinone 12μM R05 exp227	-2.55
BS-181 20μM R08 exp461	-2.54
Vemurafenib 6.6μM R08 exp434	-2.53
Vemurafenib 6.6μM R02 exp89	-2.49
LJH685 50μM R08 exp433	-2.41
Cisplatin 0.35μM R06 exp273	-2.28
Wiskostatin 3μM R07 exp422	-2.27
JQ1 0.8μM R08 exp435	-2.26
Bafilomycin-A1 0.009μM R08 exp454	-2.25
MS023 2μM R03 exp134	-2.22
Trametinib 10μM R02 exp83	-2.21
Etoposide 1μM R00 exp19	-2.19
Epothilone-B 0.0015μM R05 exp231	-2.18
Ibrutinib 1μM R07 exp372	-2.18
BI-D1870 3.15μM R02 exp66	-2.13
Nicotine 3000μM R08 exp510	-2.11
I-BRD9 4μM R07 exp365	-2.08
Thimerosal 0.85μM R08 exp529	-2.08
AICAR 240μM R03 exp116	-2.06
PU-H71 1μM R08 exp515	-2.06
LLY-283 2.6μM R06 exp290	-2.05
Salubrinal 20μM R07 exp399	-2.04
MLN-4924 0.2μM R00 exp21	-2.03
Aphidicolin 0.4μM R08 exp440	-2
GSK461364A 0.1μM R03 exp126	-2
Nocodazole 0.2μM R00 exp24	-1.98
CR131-b 0.005μM R08 exp474	-1.96
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.96
Bisphenol F 50μM R08 exp457	-1.94
Clomiphene 4.4μM R02 exp68	-1.94
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.93
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.89
Tenofovir 10μM R07 exp405	-1.88
VER-155008 3.9μM R06 exp301	-1.88
Ribavirin 10 to 15μM on day4 R04 exp160	-1.87
42°C R08 exp539	-1.86
CB-5083 0.4μM R08 exp468	-1.84
MK2206 4μM R08 exp504	-1.84
Chlorpromazine 10μM R07 exp344	-1.83
Fluvastatin 2.2μM R06 exp282	-1.83
WYE-354 6μM R02 exp90	-1.83
A-395N 10μM R05 exp219	-1.82
All-trans-Retinoic-Acid 40μM R07 exp334	-1.82
Resminostat 0.5μM R07 exp393	-1.82
Thioridazine 5μM R08 exp530	-1.82
All-trans-Retinoic-Acid 8μM R07 exp333	-1.81
CFI-400945 25μM R08 exp469	-1.81
Latrunculin-B 10μM R07 exp374	-1.81
Tanespimycin 14μM R08 exp527	-1.81
Bisphenol A 100μM R06 exp269	-1.78
Genistein 15μM R07 exp360	-1.78
QNZ 0.01μM R05 exp241	-1.78
UM0011500 10μM R05 exp246	-1.78
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.76
BRD2 inhibitor II 20μM R07 exp341	-1.74
Docosahexaenoic-acid 50μM R07 exp356	-1.73
Vinorelbine 0.001μM R05 exp249	-1.72
DABN racemic mixture R03 exp93	-1.71
Doxorubicin 0.02μM R08 exp478	-1.71

Global Fraction of Cell Lines Where Essential: 72/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	5/26
breast	2/33
central nervous system	3/56
cervix	2/4
colorectal	0/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	1/21
liver	6/20
lung	7/75
lymphocyte	3/16
ovary	2/26
pancreas	1/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 921
Expression level (log2 read counts): 4.96

Expression Distribution

Gene	Correlation
POLR2J3	0.47
JTB	0.451

SRPRB
Miro
Arf
Gtr1 RagA
G-alpha
Ras

protein localization to Golgi apparatus
Golgi to plasma membrane protein transport
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
retrograde transport, endosome to Golgi
vesicle-mediated transport to the plasma membrane
trans-Golgi network membrane
post-Golgi vesicle-mediated transport
cytosolic transport
gastrulation
trans-Golgi network
protein localization to plasma membrane
endosomal transport
protein localization to cell periphery
establishment of protein localization to membrane
GTPase activity
Golgi vesicle transport
GTP binding
protein localization to membrane
embryonic morphogenesis
protein localization to organelle
embryo development
Golgi apparatus
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport
membrane