COX7A2L

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). {ECO:0000250|UniProtKB:Q61387}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 10μM R00 exp20	-3.39
Pimelic-diphenylamide-106 5μM R00 exp28	-3.1
Oligomycin-A 2μM R00 exp25	-3.09
Rotenone 20μM R00 exp34	-3.06
Rotenone 2μM R00 exp33	-2.89
MLN-4924 2μM R00 exp22	-2.54
Oligomycin-A 20μM R00 exp26	-2.54
Calcium Ionophore 0.4μM R07 exp342	-2.52
Rapamycin 1μM R00 exp29	-2.46
Clomiphene 4.4μM R02 exp68	-2.42
Bortezomib 0.05μM R00 exp7	-2.38
Actinomycin-D 0.001μM R00 exp3	-2.24
Pterostilbene 16μM R02 exp78	-2.22
JQ1 0.8μM R08 exp435	-2.18
5-Fluorouracil 20μM R00 exp2	-2.17
Brefeldin A 0.02μM R00 exp8	-2.15
DABN 20μM R00 exp17	-2.14
Etoposide 1μM R00 exp19	-2.02
BI-6727 0.0125μM R03 exp97	-1.99
UM131593 0.2μM R03 exp106	-1.99
Nocodazole 0.2μM R00 exp24	-1.97
UM0125461 0.74μM R02 exp84	-1.89
LLY-283 2.6μM R06 exp290	-1.84
Q15 2.7μM R02 exp79	-1.76
Salinomycin 3.5μM R08 exp521	-1.75
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Hypoxia 5%O2 R04 exp191	1.91
CCCP 1μM R00 exp11	2.79
Doxycycline 10μM R00 exp18	2.81

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial respirasome assembly
mitochondrial respirasome
mitochondrial electron transport, cytochrome c to oxygen
aerobic electron transport chain
cytochrome-c oxidase activity
regulation of oxidative phosphorylation
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
regulation of ATP metabolic process
proton transmembrane transport
regulation of generation of precursor metabolites and energy
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
mitochondrion organization
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
cellular protein-containing complex assembly
nucleolus
ion transmembrane transport
oxidation-reduction process
mitochondrion
transmembrane transport
phosphorylation
ion transport
protein-containing complex assembly
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
protein-containing complex subunit organization