GAK

Entrez Summary: N/A
UniProt Summary: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-3.44
Taxol 0.004μM R03 exp103	-3.21
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.17
Sulforaphane 9μM R08 exp525	-3.16
Taxol 0.002μM R01 exp54	-3.11
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-3.03
Vincristine 0.0005μM R04 exp190	-2.86
UMK57 0.6μM R03 exp107	-2.79
Sulforaphane 9μM R08 exp526 no dilution day6	-2.74
GSK626616 14μM R08 exp485	-2.73
BML-284 0.09μM R08 exp460	-2.57
UMK57 1μM R01 exp59	-2.56
BI-2536 0.0042μM R03 exp95	-2.54
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.42
LLY-283 2.6μM R06 exp290	-2.35
Mdivi-1 15μM R05 exp217	-2.29
Thimerosal 0.85μM R08 exp529	-2.25
UM131593 0.2μM R03 exp106	-2.16
Docetaxel 0.002μM R01 exp45	-2.15
UM131593 0.1μM R01 exp58	-2.11
HMS-I1 1μM R01 exp46	-2.1
Demecolcine 0.03μM R05 exp228	-2.08
Vemurafenib 6.6μM R02 exp89	-2.03
Milciclib 2μM R08 exp502	-1.96
GSK461364A 0.005μM R03 exp125	-1.95
BI-6727 0.0125μM R03 exp97	-1.93
Epothilone-B 0.0015μM R05 exp231	-1.91
3-Bromopyruvate 7μM R04 exp175	-1.82
Colchicine 0.009μM R05 exp215	-1.81
2-Methoxyestradiol 0.55μM R07 exp310	-1.8
CAY10603 0.55μM R08 exp467	-1.77
TIC10 10μM R08 exp532	-1.76
LB-100 2μM R05 exp210	-1.75
Dorsomorphin 5μM R07 exp357	-1.74
Vemurafenib 6.6μM R08 exp434	-1.72
Citral 75μM R06 exp275	-1.7
proTAME 5μM R04 exp187	-1.7
Clomiphene 4.4μM R02 exp68	1.85
Betulinic acid 10 to 15μM on day4 R05 exp222	2.08

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

clathrin-coated pit assembly
synaptic vesicle uncoating
clathrin coat disassembly
vesicle uncoating
Golgi to lysosome transport
Golgi to vacuole transport
clathrin-dependent endocytosis
protein localization to Golgi apparatus
cyclin binding
chaperone cofactor-dependent protein refolding
protein depolymerization
de novo posttranslational protein folding
clathrin binding
de novo protein folding
synaptic vesicle endocytosis
presynaptic endocytosis
synaptic vesicle recycling
endoplasmic reticulum organization
chaperone-mediated protein folding
presynapse
post-Golgi vesicle-mediated transport
chaperone binding
lysosomal transport
synaptic vesicle cycle
vesicle-mediated transport in synapse
Golgi organization
cellular protein complex disassembly
vesicle
vacuolar transport
cytosolic transport
negative regulation of neuron projection development
negative regulation of cell projection organization
protein localization to plasma membrane
negative regulation of neuron differentiation
protein localization to cell periphery
protein folding
receptor-mediated endocytosis
protein-containing complex disassembly
negative regulation of neurogenesis
negative regulation of nervous system development