KNTC1

Entrez Summary: This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-4.42
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-3.8
UMK57 0.6μM R03 exp107	-3.59
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.4
Mdivi-1 15μM R05 exp217	-3.31
CAY10603 0.55μM R08 exp467	-2.96
BML-284 0.09μM R08 exp460	-2.92
HMS-I1 1μM R01 exp46	-2.92
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.61
2-Methoxyestradiol 0.55μM R07 exp310	-2.48
Quercetin 20μM R08 exp517	-2.44
UMK57 1μM R01 exp59	-2.41
Taxol 0.002μM R01 exp54	-2.38
Vincristine 0.0005μM R04 exp190	-2.24
Vinblastine 0.002μM R01 exp60	-2.22
LY2090314 0.003μM R08 exp500 no dilution day6	-2.15
Dorsomorphin 5μM R07 exp357	-2.04
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.02
Cabazitaxel 0.001μM R05 exp223	-1.99
Docetaxel 0.002μM R01 exp45	-1.99
Taxol 0.004μM R03 exp103	-1.95
CCT251545 20μM R07 exp326	-1.92
GSK-J4 1μM R07 exp362	-1.85
PF-06409577 20μM R07 exp389	-1.8
Adefovir 20μM R07 exp332	-1.76
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.75
Mubritinib 0.2μM R01 exp48	-1.71
Rotenone 20μM R00 exp34	1.9
Vinblastine 0.2μM R03 exp108	5.88
Nocodazole 0.2μM R02 exp64	6.55
SB743921 0.001μM R05 exp244	6.56
HMS-I1 10μM R06 exp256	6.64
DABN 20μM R00 exp17	6.66
Nocodazole 0.1μM R03 exp94	7.45
DABN racemic mixture R03 exp93	7.6
Vinblastine 0.015μM R05 exp208	8.1
R-DABN 8μM R03 exp111	8.27
Rotenone 2μM R00 exp33	8.27
Nocodazole 0.2μM R00 exp24	8.29

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	3/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

RZZ complex
kinetochore microtubule
regulation of exit from mitosis
condensed chromosome kinetochore
spindle pole
mitotic cell cycle checkpoint
regulation of mitotic nuclear division
regulation of nuclear division
cell cycle checkpoint
actin cytoskeleton
negative regulation of mitotic cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell division
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
regulation of cell cycle process
cell cycle process
regulation of cell cycle
regulation of organelle organization
cell cycle
protein-containing complex assembly
protein-containing complex subunit organization