MBTD1

Entrez Summary: N/A
UniProt Summary: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. {ECO:0000250, ECO:0000269|PubMed:19841675}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Staurosporine 0.02μM R08 exp524	-2.81
CB-5083 0.4μM R08 exp468	-2.68
UM0129480 7μM R02 exp85	-2.4
TRAIL 50ng/ml R00 exp36	-2.26
Arsenate 40μM R06 exp264	-2.17
Actinomycin-D 0.001μM R00 exp3	-2.1
Vinblastine 0.015μM R05 exp208	-2.08
Etoposide 0.3μM R05 exp199	-2.05
Bleomycin 5μM R08 exp459	-2.01
Pimelic-diphenylamide-106 5μM R00 exp28	-1.96
Dinaciclib 0.007μM R07 exp355	-1.86
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.8
SB743921 0.001μM R05 exp244	-1.79
TRAIL 5ng/ml R00 exp35	-1.74
MS023 2μM R03 exp134	-1.71
Colchicine 0.009μM R05 exp215	1.7
Rapamycin 1μM R00 exp29	1.78
LY2090314 0.003μM R08 exp500 no dilution day6	1.88
B02 10μM R08 exp453	1.89
MKC9989 10μM R03 exp133	1.89
Nocodazole 0.02μM R00 exp23	1.98
Rapamycin 10μM R00 exp30	2.03
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.11
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.18
Alpha-Amanitin 0.5μM R00 exp5	2.23
LY2090314 0.003μM R08 exp499	2.32
THZ531 0.11μM R07 exp409	2.37
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.8
THZ531 0.225μM R08 exp444	3

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

methylated histone binding
embryonic skeletal system development
skeletal system development
chordate embryonic development
embryo development ending in birth or egg hatching
chromatin organization
zinc ion binding
embryo development
chromosome organization