MLST8
Gene Information
- Official Symbol: MLST8
- Official Name: MTOR associated protein, LST8 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 64223
- UniProt: Q9BVC4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| TORC1 complex |
| TORC1 signaling |
| TORC2 complex |
| TOR signaling |
| protein serine/threonine kinase activator activity |
| activation of protein kinase B activity |
| positive regulation of TOR signaling |
| regulation of cellular response to heat |
| regulation of TOR signaling |
| cell cycle arrest |
| regulation of macroautophagy |
| activation of protein kinase activity |
| regulation of autophagy |
| positive regulation of protein serine/threonine kinase activity |
| regulation of actin cytoskeleton organization |
| regulation of actin filament-based process |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of cellular response to stress |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| regulation of transferase activity |
| regulation of catabolic process |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of protein modification process |
| regulation of organelle organization |
| cell cycle |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MAPKAP1 | 0.753 |
| PDPK1 | 0.702 |
| CD81 | 0.669 |
| RICTOR | 0.661 |
| AKT2 | 0.645 |
| DOHH | 0.622 |
| MTOR | 0.601 |
| RPTOR | 0.583 |
| NSD1 | 0.573 |
| WDR24 | 0.564 |
| BAK1 | 0.563 |
| PIK3CD | 0.539 |
| VDAC2 | 0.535 |
| TRIM28 | 0.534 |
| WDR59 | 0.524 |
| ID3 | 0.521 |
| SERF2 | 0.521 |
| SYK | 0.517 |
| ROMO1 | 0.503 |
| ZZZ3 | 0.502 |
| FBXO11 | 0.496 |
| LAMTOR4 | 0.496 |
| BAP1 | 0.493 |
| RHOH | 0.479 |
| CD19 | 0.477 |
| APAF1 | 0.471 |
| MARCH5 | 0.465 |
| CASP9 | 0.463 |
| LAMTOR2 | 0.461 |
| THG1L | 0.455 |
| BPTF | 0.452 |
| TRIM33 | 0.45 |
| MIOS | 0.446 |
| CBFB | 0.444 |
| KDSR | 0.442 |
| SSBP2 | 0.442 |
| FAF2 | 0.441 |
| RUNX1 | 0.439 |
| KLF13 | 0.439 |
| PLAA | 0.437 |
| ASXL2 | 0.433 |
| LAMTOR3 | 0.429 |
| N6AMT1 | 0.428 |
| VHL | 0.426 |
| STAU1 | 0.425 |
| UBQLN1 | 0.424 |
| TRNT1 | 0.42 |
| BCL2L11 | 0.419 |
| INTS10 | 0.419 |
| MOCS3 | 0.419 |
| TRMT10A | 0.417 |
| HCCS | 0.414 |
| PMM2 | 0.412 |
| ZNF592 | 0.409 |
| IRF2BP2 | 0.406 |
| SEC62 | 0.403 |
| ASUN | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 162/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 3/28 |
| blood | 6/28 |
| bone | 8/26 |
| breast | 9/33 |
| central nervous system | 19/56 |
| cervix | 1/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 10/21 |
| liver | 7/20 |
| lung | 13/75 |
| lymphocyte | 6/16 |
| ovary | 5/26 |
| pancreas | 3/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 7/15 |
| prostate | 1/1 |
| skin | 6/24 |
| soft tissue | 2/9 |
| thyroid | 1/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 7/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1071
- Expression level (log2 read counts): 5.45
Expression Distribution
MLST8 Expression in NALM6 Cells: 5.45
