PSAP

Entrez Summary: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-2.25
RK-33 8μM R08 exp518	-2.14
Nocodazole 0.2μM R02 exp64	-2.02
CI-1040 9.5μM R08 exp472	-2
TIC10 10μM R08 exp532	-1.98
SB202190 10μM R03 exp148	1.76
PFI-3 10μM R03 exp144	1.78
ABT-702 5μM R07 exp318	1.84
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.84
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.89
TRAIL 50ng/ml R00 exp36	1.98
Betulinic acid 10 to 15μM on day4 R05 exp222	3.95
UM0011500 5μM R05 exp245	4.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ganglioside GM1 transport to membrane
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GP1c binding
ganglioside GM1 binding
galactosylceramide catabolic process
ganglioside GT1b binding
corneocyte development
galactolipid catabolic process
cornified envelope assembly
beta-galactosidase activity
glycolipid transport
glycosylceramide catabolic process
micturition
galactosylceramide metabolic process
prostate gland growth
galactolipid metabolic process
epithelial cell differentiation involved in prostate gland development
keratinocyte development
glycosphingolipid catabolic process
ceramide transport
glycolipid catabolic process
negative regulation of hydrogen peroxide-induced cell death
negative regulation of response to reactive oxygen species
glycosylceramide metabolic process
ceramide catabolic process
negative regulation of cellular response to drug
regulation of hydrogen peroxide-induced cell death
negative regulation of response to drug
walking behavior
sphingolipid catabolic process
regulation of response to reactive oxygen species
membrane assembly
membrane lipid catabolic process
regulation of cellular response to drug
membrane biogenesis
excretion
prostate gland development
negative regulation of oxidative stress-induced cell death
negative regulation of cellular response to oxidative stress