PSMC4
Gene Information
- Official Symbol: PSMC4
- Official Name: proteasome 26S subunit, ATPase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 5704
- UniProt: P43686
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}.
Pfam Domains GO Terms
Pfam Domains
| AAA 2 |
| AAA |
| AAA 5 |
GO Terms
| proteasome-activating ATPase activity |
| cytosolic proteasome complex |
| positive regulation of RNA polymerase II transcriptional preinitiation complex assembly |
| proteasome regulatory particle, base subcomplex |
| regulation of RNA polymerase II transcriptional preinitiation complex assembly |
| proteasome accessory complex |
| positive regulation of transcription initiation from RNA polymerase II promoter |
| inclusion body |
| positive regulation of DNA-templated transcription, initiation |
| regulation of transcription initiation from RNA polymerase II promoter |
| regulation of DNA-templated transcription, initiation |
| proteasome complex |
| regulation of cellular amino acid metabolic process |
| regulation of hematopoietic stem cell differentiation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| regulation of cellular amine metabolic process |
| NIK/NF-kappaB signaling |
| anaphase-promoting complex-dependent catabolic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of G2/M transition of mitotic cell cycle |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| interleukin-1-mediated signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| antigen processing and presentation of peptide antigen via MHC class I |
| blastocyst development |
| negative regulation of cell cycle G2/M phase transition |
| positive regulation of proteasomal protein catabolic process |
| regulation of establishment of planar polarity |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of stem cell differentiation |
| tumor necrosis factor-mediated signaling pathway |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of DNA-templated transcription in response to stress |
| non-canonical Wnt signaling pathway |
| positive regulation of cellular protein catabolic process |
| positive regulation of canonical Wnt signaling pathway |
| regulation of cellular ketone metabolic process |
| Fc-epsilon receptor signaling pathway |
| negative regulation of canonical Wnt signaling pathway |
| cellular response to interleukin-1 |
| T cell receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| positive regulation of Wnt signaling pathway |
| regulation of mRNA stability |
| regulation of morphogenesis of an epithelium |
| antigen processing and presentation of exogenous antigen |
| regulation of proteasomal protein catabolic process |
| regulation of RNA stability |
| cellular response to hypoxia |
| antigen processing and presentation of peptide antigen |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| regulation of mRNA catabolic process |
| negative regulation of Wnt signaling pathway |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| regulation of proteolysis involved in cellular protein catabolic process |
| antigen processing and presentation |
| positive regulation of protein catabolic process |
| negative regulation of cell cycle phase transition |
| innate immune response-activating signal transduction |
| ATPase activity |
| cellular response to tumor necrosis factor |
| Fc receptor signaling pathway |
| regulation of cellular protein catabolic process |
| positive regulation of protein complex assembly |
| regulation of animal organ morphogenesis |
| activation of innate immune response |
| response to tumor necrosis factor |
| synapse |
| regulation of canonical Wnt signaling pathway |
| protein deubiquitination |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| protein polyubiquitination |
| negative regulation of mitotic cell cycle |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| post-translational protein modification |
| positive regulation of response to biotic stimulus |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| in utero embryonic development |
| response to oxygen levels |
| regulation of protein catabolic process |
| signal transduction by protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| positive regulation of catabolic process |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| positive regulation of multi-organism process |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| immune response-activating signal transduction |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| activation of immune response |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| regulation of proteolysis |
| regulation of cell cycle process |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| embryo development |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PSMA6 | 0.536 |
| POLR2J3 | 0.524 |
| PSMC6 | 0.492 |
| PSMD1 | 0.484 |
| ZFAND5 | 0.483 |
| SUPT6H | 0.475 |
| PWP2 | 0.462 |
| PSMC1 | 0.462 |
| DTL | 0.455 |
| PSMD11 | 0.453 |
| TBC1D3H | 0.452 |
| PSMB4 | 0.443 |
| ANKLE2 | 0.436 |
| PSMD14 | 0.435 |
| TBC1D3G | 0.435 |
| UQCRH | 0.434 |
| CDCA3 | 0.429 |
| TBC1D3C | 0.429 |
| SMG7 | 0.429 |
| RPS2 | 0.429 |
| CHD4 | 0.427 |
| TCEB3C | 0.425 |
| CACNA1A | 0.423 |
| RRP7A | 0.423 |
| SH3BP1 | 0.423 |
| PAN2 | 0.422 |
| NUPL1 | 0.422 |
| GOLGA8O | 0.42 |
| MAP7D1 | 0.419 |
| PSMC2 | 0.419 |
| HAP1 | 0.418 |
| COPB1 | 0.417 |
| TICRR | 0.417 |
| RPS28 | 0.416 |
| GOLGA6L6 | 0.416 |
| PAN3 | 0.412 |
| RPA2 | 0.412 |
| CDC73 | 0.411 |
| PSMB1 | 0.408 |
| TBC1D3F | 0.408 |
| FBXO5 | 0.408 |
| COPE | 0.407 |
| ORC6 | 0.406 |
| TCEB3CL | 0.406 |
| TSPY1 | 0.405 |
| OSBP | 0.405 |
| WDR43 | 0.404 |
| DOCK6 | 0.404 |
| MYO1H | 0.402 |
| RRP15 | 0.402 |
| PSMD3 | 0.401 |
| PSMD2 | 0.4 |
| CSNK1A1 | 0.4 |
| ITGA2B | 0.4 |
| CDC45 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 55/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 5/28 |
| blood | 0/28 |
| bone | 3/26 |
| breast | 7/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 4/75 |
| lymphocyte | 2/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 3/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 180
- Expression level (log2 read counts): 6.12
Expression Distribution
PSMC4 Expression in NALM6 Cells: 6.12
