RRM2
Gene Information
- Official Symbol: RRM2
- Official Name: ribonucleotide reductase regulatory subunit M2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6241
- UniProt: P31350
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Pfam Domains GO Terms
Pfam Domains
| Ribonuc red sm |
GO Terms
| ribonucleoside-diphosphate reductase complex |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| ferric iron binding |
| deoxyribonucleotide biosynthetic process |
| regulation of transcription involved in G1/S transition of mitotic cell cycle |
| nucleobase-containing small molecule interconversion |
| protein heterotetramerization |
| deoxyribonucleotide metabolic process |
| negative regulation of G0 to G1 transition |
| regulation of G0 to G1 transition |
| protein heterooligomerization |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| protein tetramerization |
| DNA replication |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| negative regulation of cell cycle process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| protein complex oligomerization |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| carbohydrate derivative biosynthetic process |
| mitotic cell cycle |
| regulation of cell cycle process |
| protein homodimerization activity |
| organophosphate metabolic process |
| oxidation-reduction process |
| cell cycle process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| organic cyclic compound biosynthetic process |
| cell cycle |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 737/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 891
- Expression level (log2 read counts): 8.92
Expression Distribution
RRM2 Expression in NALM6 Cells: 8.92
