TGS1

Entrez Summary: N/A
UniProt Summary: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PF-06409577 20μM R07 exp389	-2.23
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.08
Zebularine 20μM R07 exp423	-1.97
Oligomycin-A 2μM R00 exp25	-1.93
ZLN024 50μM R08 exp538	-1.92
VE-822 0.04μM R06 exp300	-1.83
IWR1 50μM R08 exp495	-1.76
HMS-I2 5μM R06 exp287	-1.72
LY2090314 0.003μM R08 exp499	-1.72
DABN racemic mixture R03 exp93	1.74
MLN-4924 2μM R00 exp22	1.83
Etoposide 0.3μM R05 exp199	2.31

Global Fraction of Cell Lines Where Essential: 128/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	1/28
bone	4/26
breast	7/33
central nervous system	5/56
cervix	0/4
colorectal	6/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	4/21
liver	3/20
lung	15/75
lymphocyte	6/16
ovary	2/26
pancreas	2/24
peripheral nervous system	4/16
plasma cell	5/15
prostate	1/1
skin	1/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	7/29
uterus	1/5

Expression Distribution