Table of Contents

Vincristine 0.0005μM R04 exp190

Mechanism of Action

Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)

Technical Notes

Compound References

  • PubChem Name: Vincristine sulfate
  • Synonyms: Leurocristine sulfate; 22-Oxovincaleukoblastine sulfate
  • CAS #: 2068-78-2
  • PubChem CID: 249332
  • IUPAC: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
  • INCHI Name: InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
  • INCHI Key: AQTQHPDCURKLKT-JKDPCDLQSA-N
  • Molecular Weight: 923
  • Canonical SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
  • Isomeric SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
  • Molecular Formula: C46H58N4O14S

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: V8879
  • Lot #: N/A

Compound Characterization

  • LCMS: Tr 1.08 min, m/z 825+ [M+H]+, 839- [M-H+O]-

Dose Response Curve

  • Platform ID: Vincristine
  • Min: -7.1789; Max: 86.5763





IC Concentration (µM)
IC10 N/A
IC20 0.0005
IC30 0.0006
IC40 0.0006
IC50 0.0007
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
56/22ScoresViewViewViewViewView