EEF1E1
Gene Information
- Official Symbol: EEF1E1
- Official Name: eukaryotic translation elongation factor 1 epsilon 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9521
- UniProt: O43324
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Positive modulator of ATM response to DNA damage. {ECO:0000250|UniProtKB:Q9D1M4}.
Pfam Domains GO Terms
Pfam Domains
| GST C |
GO Terms
| aminoacyl-tRNA synthetase multienzyme complex |
| positive regulation of cellular senescence |
| positive regulation of cell aging |
| positive regulation of DNA damage response, signal transduction by p53 class mediator |
| positive regulation of signal transduction by p53 class mediator |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of cellular senescence |
| tRNA aminoacylation for protein translation |
| regulation of cell aging |
| tRNA aminoacylation |
| amino acid activation |
| positive regulation of response to DNA damage stimulus |
| regulation of signal transduction by p53 class mediator |
| tRNA metabolic process |
| regulation of response to DNA damage stimulus |
| cellular amino acid metabolic process |
| translation |
| peptide biosynthetic process |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| regulation of cellular response to stress |
| cellular amide metabolic process |
| nucleolus |
| carboxylic acid metabolic process |
| oxoacid metabolic process |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCCP 0.1μM R00 exp10 | -2.19 |
| ETC-159 50μM R08 exp480 | -1.78 |
| Myriocin 25μM R06 exp293 | -1.76 |
| Geldanamycin 0.015 to 0.025μM on day4 R07 exp316 | -1.7 |
| BI-2536 0.02μM R03 exp96 | 1.88 |
| Artemisinin 50μM R08 exp450 | 2.15 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.545 |
| ATXN10 | 0.524 |
| ALG1 | 0.516 |
| TRMT10A | 0.502 |
| TMEM41B | 0.501 |
| ELP2 | 0.496 |
| DPAGT1 | 0.494 |
| PDAP1 | 0.483 |
| VEZT | 0.479 |
| RNMT | 0.47 |
| RPP21 | 0.467 |
| TRMT5 | 0.466 |
| DHRSX | 0.463 |
| TSEN54 | 0.458 |
| C14orf166 | 0.457 |
| TPRKB | 0.455 |
| RTCB | 0.455 |
| PMM2 | 0.454 |
| URM1 | 0.453 |
| TTC4 | 0.453 |
| PPCS | 0.451 |
| GTF3C2 | 0.45 |
| TEN1 | 0.45 |
| EIF1AX | 0.449 |
| GTF3C4 | 0.448 |
| POLR3H | 0.448 |
| HAUS8 | 0.447 |
| RPTOR | 0.445 |
| DOHH | 0.443 |
| SSB | 0.438 |
| SEC62 | 0.435 |
| ASB7 | 0.434 |
| ATP5J | 0.431 |
| CRCP | 0.429 |
| TPK1 | 0.428 |
| UAP1 | 0.427 |
| TRMT61A | 0.426 |
| DHPS | 0.425 |
| DOLK | 0.425 |
| SRP68 | 0.422 |
| MED4 | 0.422 |
| EXOC4 | 0.421 |
| TRIAP1 | 0.42 |
| AARS | 0.42 |
| ELP3 | 0.42 |
| MAML1 | 0.418 |
| DDX1 | 0.418 |
| MBTPS2 | 0.418 |
| LSM10 | 0.418 |
| PYROXD1 | 0.418 |
| GEMIN6 | 0.418 |
| ALG6 | 0.417 |
| ALG2 | 0.417 |
| PAXIP1 | 0.416 |
| DR1 | 0.415 |
| UHRF1 | 0.415 |
| GTF3C6 | 0.413 |
| SLC25A19 | 0.413 |
| POLR3B | 0.411 |
| IRF2BP2 | 0.411 |
| PELO | 0.411 |
| POLR3C | 0.409 |
| CCDC101 | 0.409 |
| GTF3C3 | 0.408 |
| SRP14 | 0.408 |
| GMPPB | 0.406 |
| FH | 0.405 |
| OSGEP | 0.403 |
| ELP6 | 0.401 |
| TBCB | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2598
- Expression level (log2 read counts): 5.26
Expression Distribution
EEF1E1 Expression in NALM6 Cells: 5.26
