TSSC1

Gene Information

Official Symbol: EIPR1
Official Name: EARP complex and GARP complex interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 7260
UniProt: Q53HC9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-3.17
Amiloride 100μM R08 exp447	-3.11
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.95
Hippuristanol 0.12μM R08 exp488	-2.91
Vemurafenib 6.6μM R08 exp434	-2.7
B02 10μM R08 exp453	-2.49
Bisphenol A 100μM R06 exp269	-2.41
Tubacin 1.6μM R07 exp416	-2.41
BVD-523 15μM R02 exp67	-2.38
42°C R08 exp539	-2.36
Bisphenol F 50μM R08 exp457	-2.36
Tanespimycin 14μM R08 exp527	-2.36
Myriocin 25μM R06 exp293	-2.27
Rifampicin 30μM R08 exp430	-2.19
Thioridazine 5μM R08 exp530	-2.19
Wiskostatin 3μM R07 exp422	-2.18
Ibrutinib 10μM R08 exp442	-2.16
FK-506 5μM R07 exp358	-2.14
FTY720 3μM R08 exp483	-2.14
IU1-47 25μM R04 exp182	-2.12
Arsenic trioxide 60μM R08 exp449	-2.1
FK-506 30μM R07 exp359	-2.1
DABN 20μM R00 exp17	-2.07
Mubritinib 0.2μM R01 exp48	-2.05
Chloroquine 32μM R08 exp470	-2.02
Momordin-Ic 10μM R08 exp506	-2
Bleomycin 5μM R08 exp459	-1.97
BS-181 20μM R08 exp461	-1.97
Bortezomib 0.05μM R00 exp7	-1.94
Cerivastatin 0.15μM R05 exp226	-1.94
Tubastatin-A 2.5μM R07 exp417	-1.93
Ribavirin 10 to 15μM on day4 R04 exp160	-1.92
Salubrinal 20μM R07 exp399	-1.92
Wortmannin 0.5μM R00 exp37	-1.92
Trametinib 10μM R02 exp83	-1.9
Wortmannin 5μM R00 exp38	-1.89
Clomiphene 4.4μM R02 exp68	-1.88
Mubritinib 0.2μM R02 exp65	-1.87
Lapatinib 5μM R01 exp47	-1.85
Etoposide 0.3μM R05 exp199	-1.84
Monensin 0.3μM R08 exp507	-1.84
PU-H71 1μM R08 exp515	-1.84
Rapamycin 10μM R00 exp30	-1.84
Cannabidiol 20μM R08 exp466	-1.79
Doxorubicin 0.02μM R08 exp478	-1.78
QNZ 0.01μM R08 exp439	-1.76
CB-839 10μM R05 exp224	-1.75
Trimetrexate 0.03μM R08 exp535	-1.75
MLN-4924 0.2μM R00 exp21	-1.74
Rotenone 20μM R00 exp34	-1.73
CI-1040 9.5μM R08 exp472	-1.72
Etoposide 10μM R00 exp20	-1.72
Selumetinib 20μM R02 exp81	-1.71

Gene	Correlation
GPR107	0.495
VPS54	0.483
VPS52	0.446
ZFAT	0.433
SCYL1	0.429
JTB	0.414

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1526
Expression level (log2 read counts): 4.65

Expression Distribution