ZBTB7A
Gene Information
- Official Symbol: ZBTB7A
- Official Name: zinc finger and BTB domain containing 7A
- Aliases and Previous Symbols: N/A
- Entrez ID: 51341
- UniProt: O95365
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| BTB |
GO Terms
| DNA-dependent protein kinase complex |
| double-strand break repair via classical nonhomologous end joining |
| transcription corepressor binding |
| erythrocyte maturation |
| negative regulation of androgen receptor signaling pathway |
| NuRD complex |
| regulation of androgen receptor signaling pathway |
| histone acetyltransferase binding |
| erythrocyte development |
| activating transcription factor binding |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| negative regulation of Notch signaling pathway |
| androgen receptor binding |
| SMAD binding |
| regulation of transcription regulatory region DNA binding |
| double-strand break repair via nonhomologous end joining |
| site of double-strand break |
| myeloid cell development |
| non-recombinational repair |
| regulation of alternative mRNA splicing, via spliceosome |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of intracellular steroid hormone receptor signaling pathway |
| regulation of glycolytic process |
| erythrocyte differentiation |
| regulation of carbohydrate catabolic process |
| erythrocyte homeostasis |
| regulation of mRNA splicing, via spliceosome |
| regulation of Notch signaling pathway |
| fat cell differentiation |
| myeloid cell homeostasis |
| B cell differentiation |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| regulation of DNA binding |
| anatomical structure maturation |
| regulation of RNA splicing |
| regulation of mRNA processing |
| negative regulation of cellular response to growth factor stimulus |
| positive regulation of NF-kappaB transcription factor activity |
| B cell activation |
| cell maturation |
| regulation of generation of precursor metabolites and energy |
| chromatin remodeling |
| protein localization to nucleus |
| double-strand break repair |
| homeostasis of number of cells |
| regulation of carbohydrate metabolic process |
| myeloid cell differentiation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| lymphocyte differentiation |
| developmental maturation |
| transcription corepressor activity |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| positive regulation of DNA-binding transcription factor activity |
| regulation of cellular response to growth factor stimulus |
| regulation of mRNA metabolic process |
| leukocyte differentiation |
| regulation of binding |
| lymphocyte activation |
| regulation of DNA-binding transcription factor activity |
| regulation of small molecule metabolic process |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| DNA repair |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| chromatin organization |
| protein localization to organelle |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| negative regulation of transcription by RNA polymerase II |
| leukocyte activation |
| regulation of catabolic process |
| chromosome organization |
| cell activation |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cell development |
| RNA metabolic process |
| regulation of cell death |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15792
- Expression level (log2 read counts): 5.74
Expression Distribution
ZBTB7A Expression in NALM6 Cells: 5.74
