Table of Contents

Pyridostatin 4μM R05 exp240

Mechanism of Action

Binds and stabilizes telomeric and interstitial G-quadruplexes

Technical Notes

Protein References

  • PubChem Name: Pyridostatin
  • Synonyms: N/A
  • CAS #: 1085412-37-8
  • PubChem CID: 25227847
  • IUPAC: 4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide
  • INCHI Name: InChI=1S/C31H32N8O5/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41)
  • INCHI Key: VGHSATQVJCTKEF-UHFFFAOYSA-N
  • Molecular Weight: 596.6
  • Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN
  • Isomeric SMILES: N/A
  • Molecular Formula: C31H32N8O5

Protein Supplier

  • Supplier Name: Chemietek
  • Catalog #: CT-PYRI
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: [M+H]+ Calcd for C31H33N8O5 597.2569; found 597.2543

Dose Response Curve

  • Platform ID: Pyridostatin
  • Min: -4.5804; Max: 98.7377





IC Concentration (µM)
IC10 N/A
IC20 3.3625
IC30 4.0583
IC40 4.7348
IC50 5.4543
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
11/38ScoresViewViewViewViewView