Table of Contents

BVD-523 15μM R02 exp67

Mechanism of Action

Inhibits ERK1/2, ATP-competitive

Technical Notes

Protein References

  • PubChem Name: Ulixertinib
  • Synonyms: BVD-523; VRT752271
  • CAS #: 869886-67-9
  • PubChem CID: 11719003
  • IUPAC: N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1H-pyrrole-2-carboxamide
  • INCHI Name: InChI=1S/C21H22Cl2N4O2/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29)/t19-/m1/s1
  • INCHI Key: KSERXGMCDHOLSS-LJQANCHMSA-N
  • Molecular Weight: 433.3
  • Canonical SMILES: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl
  • Isomeric SMILES: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl
  • Molecular Formula: C21H22Cl2N4O2

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S7854
  • Lot #: S785401

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H22Cl2N4O2 433.11926; found 433.1203

Dose Response Curve

  • Platform ID: BVD-523
  • Min: -21.4275; Max: 66.0260





IC Concentration (µM)
IC10 N/A
IC20 17.1654
IC30 17.9440
IC40 18.6085
IC50 19.2400
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
33/19ScoresViewViewViewViewView