NXT1

Entrez Summary: N/A
UniProt Summary: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04μM R07 exp418	-1.87
Selumetinib 20μM R02 exp81	1.81
Actinomycin-D 0.01μM R00 exp4	1.83
AICAR 240μM R05 exp211	1.83
Etoposide 0.3μM R05 exp199	1.93
CI-1040 9.5μM R08 exp472	1.98
Aphidicolin 0.4μM R08 exp440	2.01
RO-3307 4.7μM R02 exp80	2.1
Pimelic-diphenylamide-106 5μM R00 exp28	2.12
Diepoxybutane 3μM R07 exp354	2.28
Benzoate 20000μM R08 exp456	2.48
MLN-4924 2μM R00 exp22	2.53
Mitomycin-C 0.06μM R08 exp503	2.77
5-Fluorouracil 20μM R00 exp2	3.03
Etoposide 1μM R00 exp19	3.03
Rotenone 20μM R00 exp34	4.12
Actinomycin-D 0.001μM R00 exp3	5.41

Global Fraction of Cell Lines Where Essential: 94/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	1/28
bone	1/26
breast	4/33
central nervous system	8/56
cervix	0/4
colorectal	4/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	4/20
lung	8/75
lymphocyte	2/16
ovary	2/26
pancreas	6/24
peripheral nervous system	8/16
plasma cell	1/15
prostate	1/1
skin	1/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

nuclear pore central transport channel
Ran GTPase binding
nuclear pore
protein import into nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
import into nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
protein import
protein export from nucleus
mRNA transport
nuclear export
protein localization to nucleus
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
nuclear speck
establishment of protein localization to organelle
protein localization to organelle
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
gene expression