Dinaciclib 0.007μM R07 exp355

Mechanism of Action

Inhibits CDK2, CDK5, CDK1, CDK9

  • Class / Subclass 1: Cell Cycle / Cell Cycle Inhibitor
  • Class / Subclass 2: Signal Transduction / Kinase Inhibitor
  • Class / Subclass 3: Gene Regulation / Transcription Inhibitor

Technical Notes

Compound References

  • PubChem Name: Dinaciclib
  • Synonyms: SCH 727965
  • CAS #: 779353-01-4
  • PubChem CID: 46926350
  • IUPAC: 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
  • INCHI Name: InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
  • INCHI Key: PIMQWRZWLQKKBJ-SFHVURJKSA-N
  • Molecular Weight: 396.5
  • Canonical SMILES: CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
  • Isomeric SMILES: CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
  • Molecular Formula: C21H28N6O2

Compound Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: D479725
  • Lot #: 2-MJS-149-1

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H28N6O2 397.23465; found 397.23573

Dose Response Curve

  • Platform ID: Dinaclib
  • Min: -9.1162; Max: 88.5880





IC Concentration (µM)
IC10 N/A
IC20 0.0052
IC30 0.0064
IC40 0.0077
IC50 0.0093
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 7nM
  • Days of incubation: 8
  • Doublings: 0.5
  • Numbers of reads: 18702654

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/24ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1