Nicotine 3000μM R08 exp510

Agonist for nicotinic acetylcholine receptors (nAChRs)

PubChem Name: Nicotine
Synonyms: N/A
CAS #: 54-11-5
PubChem CID: 89594
IUPAC: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
INCHI Name: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
INCHI Key: SNICXCGAKADSCV-JTQLQIEISA-N
Molecular Weight: 162.23
Canonical SMILES: CN1CCCC1C2=CN=CC=C2
Isomeric SMILES: CN1CCC[C@H]1C2=CN=CC=C2
Molecular Formula: C10H14N2

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
17/5	Scores	View	View	View	View	View

Screen	Correlation	Plot
PF-06409577 20μM R07 exp389	0.064	View
WYE-354 6μM R02 exp90	0.056	View
Thioridazine 5μM R08 exp530	0.051	View
Vemurafenib 6.6μM R02 exp89	0.051	View
EPZ-5676 30μM R05 exp233	0.084	View
BS-181 20μM R08 exp461	0.082	View
Azithromycin 100μM R08 exp452	0.08	View
MK2206 4μM R08 exp504	0.07	View
FTY720 3μM R08 exp483	0.066	View
Bafilomycin-A1 0.009μM R08 exp454	0.063	View
Momordin-Ic 10μM R08 exp506	0.062	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.056	View
Chloroquine 32μM R08 exp470	0.055	View
LJH685 50μM R08 exp433	0.054	View
BVD-523 15μM R02 exp67	0.054	View
Clomiphene 4.4μM R02 exp68	0.054	View
Chlorpromazine 10μM R07 exp344	0.053	View
CCT251545 20μM R07 exp326	0.052	View
B02 10μM R08 exp453	0.052	View
Monensin 0.3μM R08 exp507	0.051	View

GO Term	Fold Change	Genes
KICSTOR complex	552.30	ITFG2,KPTN
GATOR1 complex	552.30	NPRL3,NPRL2
negative regulation of TORC1 signaling	53.88	NPRL3,ITFG2,NPRL2,KPTN
cellular response to amino acid starvation	46.02	NPRL3,ITFG2,NPRL2,KPTN
response to amino acid starvation	43.32	NPRL3,ITFG2,NPRL2,KPTN
negative regulation of TOR signaling	33.47	NPRL3,ITFG2,NPRL2,KPTN
regulation of TORC1 signaling	25.69	NPRL3,ITFG2,NPRL2,KPTN