Q15 2.7μM R02 exp79
Mechanism of Action
Putative condensin inhibitor
- Class / Subclass 1: Cell Cycle / Chromosome Dynamics Inhibitor
Technical Notes
Compound References
- PubChem Name: N/A
- Synonyms: N/A
- CAS #: 1071780-64-7
- PubChem CID: N/A
- IUPAC: N/A
- INCHI Name: N/A
- INCHI Key: N/A
- Molecular Weight: 584.0421
- Canonical SMILES: N/A
- Isomeric SMILES: N/A
- Molecular Formula: C31H27ClFN7O2
Compound Supplier
- Supplier Name: In house - University of Montreal - Chemistry Platform
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C31H27ClFN7O2 584.19716; found 584.19427
Dose Response Curve
- Platform ID: Q15
- Min: -15.2028; Max: 99.7587
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 2.4826 |
| IC30 | 2.6903 |
| IC40 | 2.8735 |
| IC50 | 3.0525 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 02
- Dose: 2.7µM
- Days of incubation: 8
- Doublings: 0.6
- Numbers of reads: 11718749
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 23/34 | Scores |
Q15 2.7μM R02 exp79
Q15 2.7μM R02 exp79 vs Vemurafenib 6.6μM R02 exp89
Q15 2.7μM R02 exp79 vs Vemurafenib 6.6μM R08 exp434
Q15 2.7μM R02 exp79 vs UM0125461 0.74μM R02 exp84
Q15 2.7μM R02 exp79 vs WYE-354 6μM R02 exp90
Q15 1 to 2μM on day4 R04 exp164 vs Q15 2.7μM R02 exp79
Clomiphene 4.4μM R02 exp68 vs Q15 2.7μM R02 exp79
BH1 1μM R04 exp169 vs Q15 2.7μM R02 exp79
Bafilomycin-A1 0.009μM R08 exp454 vs Q15 2.7μM R02 exp79
CFI-400945 25μM R08 exp469 vs Q15 2.7μM R02 exp79
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Q15 2.7μM R02 exp79
Bortezomib 0.05μM R00 exp7 vs Q15 2.7μM R02 exp79
FTY720 3μM R08 exp483 vs Q15 2.7μM R02 exp79
