TOMM22

Entrez Summary: N/A
UniProt Summary: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. {ECO:0000269|PubMed:10982837}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.7
Hinokiflavone 12μM R08 exp487	1.73
Deferoxamine 11μM R07 exp350	1.75
MK-1775 0.32μM R02 exp75	1.81
TIC10 10μM R08 exp532	1.83
Rotenone 20μM R00 exp34	1.92
Pimelic-diphenylamide-106 5μM R00 exp28	2.41

Global Fraction of Cell Lines Where Essential: 731/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

protein insertion into mitochondrial outer membrane
outer mitochondrial membrane organization
mitochondrial outer membrane translocase complex
establishment of protein localization to mitochondrial membrane
protein transmembrane transporter activity
protein insertion into mitochondrial membrane
protein insertion into membrane
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial membrane organization
protein import
macroautophagy
mitochondrial outer membrane
mitochondrial transport
process utilizing autophagic mechanism
autophagy
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
protein localization to organelle
membrane organization
intracellular protein transport
mitochondrion
transmembrane transport
protein transport
intracellular transport
peptide transport
regulation of apoptotic process
regulation of programmed cell death
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization