CCDC116 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: CCDC116
Official Name: coiled-coil domain containing 116
Aliases and Previous Symbols: N/A
Entrez ID: 164592
UniProt: Q8IYX3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-2.37
Etoposide 1μM R00 exp19	-2.05
Rotenone 20μM R00 exp34	-2.01
Actinomycin-D 0.01μM R00 exp4	-1.8
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.98
CB-839 10μM R05 exp224	2.01

Gene	Correlation
TCEB3CL2	0.517
TCEB3C	0.5
POLA1	0.499
EXOSC9	0.499
PSMB4	0.492
CHD4	0.485
PSMA7	0.485
TBC1D3H	0.48
RPL35	0.479
PSMA6	0.478
TCEB3CL	0.474
MT1E	0.473
UPF1	0.47
CDC45	0.469
GOLGA8O	0.469
CBWD5	0.467
ATP6V1B2	0.466
CBWD3	0.466
COL2A1	0.465
POLR2J3	0.464
RPS12	0.461
PSMC5	0.461
NUPL1	0.458
KRT78	0.454
DDX56	0.454
TBC1D3F	0.453
RILPL2	0.452
SLC6A17	0.448
POLA2	0.446
GOLGA6L1	0.446
CCNA2	0.444
GID4	0.444
LOC643669	0.444
RPL6	0.443
PPM1D	0.442
HIVEP3	0.441
CACTIN	0.44
PAF1	0.439
C14orf93	0.439
XYLT2	0.439
CBWD6	0.437
DDTL	0.436
EXOSC6	0.435
RPS5	0.435
ZNF574	0.434
TICRR	0.434
RPS7	0.433
WDR75	0.432
ART5	0.43
BYSL	0.43
NARFL	0.429
RPS2	0.429
TWISTNB	0.429
SLC4A1	0.429
CHAF1A	0.428
UTP3	0.428
PSMB1	0.428
SSH2	0.426
CLN6	0.424
ZNF541	0.423
NELFCD	0.423
VASN	0.422
NPIPB5	0.421
MCOLN1	0.421
PSMB2	0.42
TP53TG3D	0.42
CCDC64B	0.42
PWP2	0.42
MYO1H	0.418
TP53TG3B	0.418
TP53TG3	0.418
TBC1D3G	0.417
TP53TG3C	0.417
PSMD1	0.417
LRR1	0.417
ATP13A1	0.416
NOL10	0.414
SMG7	0.413
RAD51	0.413
ACSF2	0.412
TBC1D3	0.412
ZFAND5	0.412
CEBPZ	0.412
EXOSC5	0.411
XAB2	0.41
NBPF10	0.41
HIST2H3A	0.41
HIST2H3C	0.409
ANKLE1	0.409
DISP2	0.409
IK	0.408
MADCAM1	0.408
CDT1	0.407
CEP192	0.406
RRP7A	0.406
PSMC2	0.406
TPX2	0.406
GOLGA6L6	0.406
S1PR4	0.405
PSMD14	0.405
KCTD17	0.403
TIMELESS	0.403
DTL	0.403
DDX47	0.403
DOCK6	0.403
ACBD4	0.403
TBC1D3K	0.402
PSMD2	0.402
TBC1D3L	0.402
PLA2G4F	0.402
C1QTNF9B	0.401
ZNF830	0.401
TBC1D3E	0.401
TBC1D3I	0.401
TFIP11	0.4
GOLGA8R	0.4
CTR9	0.4
PAN3	0.4
TBC1D3C	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2021
Expression level (log2 read counts): -0.29

Expression Distribution

Last modified: 2026/01/07 22:36
by 127.0.0.1