KCMF1

Entrez Summary: N/A
UniProt Summary: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269|PubMed:15581609}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.77
Ethanol 0.01 R05 exp234	-2.35
Olaparib 4μM R08 exp512	-2.33
Bortezomib 0.005μM R00 exp6	-2.23
ML-792 0.2μM R08 exp505	-2.22
FK-506 30μM R07 exp359	-2.03
Latrunculin-B 10μM R07 exp374	-2.01
Vemurafenib 6.6μM R02 exp89	-1.97
ZLN024 50μM R08 exp538	-1.96
Citral 50μM R06 exp274	-1.91
Vemurafenib 6.6μM R08 exp434	-1.9
Doxycycline 10μM R00 exp18	-1.86
Rapamycin 10μM R00 exp30	-1.83
Wortmannin 0.5μM R00 exp37	-1.8
Amiloride 100μM R08 exp447	-1.78
Thimerosal 0.85μM R08 exp529	-1.76
Geldanamycin 0.01μM R05 exp235	-1.74
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.72
B02 10μM R08 exp453	-1.7
Arsenate 40μM R06 exp264	1.91
GSK461364A 0.005μM R03 exp125	1.96
Actinomycin-D 0.01μM R00 exp4	2.28
MLN-4924 2μM R00 exp22	2.56
BI-2536 0.0042μM R03 exp95	3
BI-6727 0.0125μM R03 exp97	3.05
42°C R08 exp539	3.57

Global Fraction of Cell Lines Where Essential: 278/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	8/28
blood	8/28
bone	4/26
breast	18/33
central nervous system	22/56
cervix	0/4
colorectal	8/17
esophagus	9/13
fibroblast	0/1
gastric	9/16
kidney	5/21
liver	7/20
lung	34/75
lymphocyte	6/16
ovary	6/26
pancreas	11/24
peripheral nervous system	2/16
plasma cell	4/15
prostate	0/1
skin	11/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	10/29
uterus	0/5

Expression Distribution

ZZ
Di19

ficolin-1-rich granule lumen
nucleic acid binding
ubiquitin protein ligase activity
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
protein ubiquitination
regulated exocytosis
leukocyte mediated immunity
protein modification by small protein conjugation
exocytosis
zinc ion binding
leukocyte activation
protein modification by small protein conjugation or removal
secretion by cell
export from cell
cell activation
immune effector process
secretion
immune response
extracellular region
vesicle-mediated transport