MAEA

Entrez Summary: N/A
UniProt Summary: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. {ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FK-506 30μM R07 exp359	-3.32
Milciclib 2μM R08 exp502	-3.02
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.62
WYE-354 6μM R02 exp90	-2.55
42°C R08 exp539	-2.43
MK-1775 0.32μM R02 exp75	-2.37
Resveratrol 16μM R03 exp147	-2.34
JQ1 0.8μM R08 exp435	-2.31
Diepoxybutane 3μM R07 exp354	-2.13
Hydroxyurea 100μM R07 exp329	-2.13
Palbociclib 1μM R07 exp382	-2.11
BML-284 0.09μM R08 exp460	-2.08
Cryptotanshinone 12μM R05 exp227	-2.02
TRAIL 5ng/ml R00 exp35	-2.01
2-Deoxy-D-glucose 800μM R05 exp214	-2
Vinblastine 0.2μM R03 exp108	-2
Caffeine 2600μM R08 exp463	-1.98
Mdivi-1 15μM R05 exp217	-1.91
Pterostilbene 16μM R02 exp78	-1.9
Bortezomib 0.005μM R00 exp6	-1.86
UM0129480 7μM R02 exp85	-1.79
Wortmannin 5μM R00 exp38	-1.77
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.76
CoCl2 18μM R07 exp346	-1.71
TRAIL 50ng/ml R00 exp36	-1.7
Dexamethasone 0.006μM R07 exp351	1.71
Cerivastatin 0.15μM R05 exp226	1.88
Tubacin 1.6μM R07 exp416	1.97
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2
Rapamycin 0.001μM R08 exp429	2.17
Azithromycin 100μM R08 exp452	2.26
Dimethyloxaloylglycine 100μM R05 exp229	2.48
Arsenate 40μM R06 exp264	2.54
AICAR 240μM R05 exp211	2.66
Rapamycin 10μM R00 exp30	3.02
Rapamycin 1μM R00 exp29	3.07
Fluvastatin 2.2μM R06 exp282	3.17
Rapamycin 2μM R07 exp306	3.58
AICAR 240μM R03 exp116	3.59
GSK626616 14μM R08 exp485	4.38

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

enucleate erythrocyte development
GID complex
actomyosin contractile ring
enucleate erythrocyte differentiation
erythrocyte maturation
negative regulation of myeloid cell apoptotic process
negative regulation of gluconeogenesis
regulation of myeloid cell apoptotic process
erythrocyte development
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
myeloid cell development
erythrocyte differentiation
erythrocyte homeostasis
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
ubiquitin ligase complex
myeloid cell homeostasis
nuclear matrix
regulation of glucose metabolic process
spindle
anatomical structure maturation
regulation of cellular carbohydrate metabolic process
cell maturation
homeostasis of number of cells
regulation of carbohydrate metabolic process
myeloid cell differentiation
developmental maturation
ubiquitin-protein transferase activity
actin binding
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
cytoskeleton
regulation of small molecule metabolic process
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
hemopoiesis