SAP130

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.74
Bortezomib 0.005μM R00 exp6	-2.48
TRAIL 5ng/ml R00 exp35	-2.42
Etoposide 1μM R00 exp19	-2.34
Trametinib 10μM R02 exp83	-2.33
Golgicide-A 4μM R03 exp122	-2.22
Bortezomib 0.05μM R00 exp7	-2.14
Aphidicolin 0.4μM R08 exp440	-2.03
Taxol 0.004μM R03 exp103	-2.03
2-Methoxyestradiol 0.55μM R07 exp310	-2.01
Pimelic-diphenylamide-106 5μM R00 exp28	-2
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.96
Cidofovir 10μM R07 exp345	-1.95
Rotenone 20μM R00 exp34	-1.89
Etoposide 10μM R00 exp20	-1.88
Brefeldin A 0.02μM R00 exp8	-1.85
Rifampicin 10μM R00 exp32	-1.85
Wortmannin 5μM R00 exp38	-1.85
Actinomycin-D 0.001μM R00 exp3	-1.8
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.79
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	-1.75
Diepoxybutane 3μM R07 exp354	-1.73
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.72
Cycloheximide 0.02μM R00 exp14	-1.71
Epothilone-B 0.0015μM R05 exp231	-1.71
Thapsigargin 0.005μM R07 exp407	-1.71
All-trans-Retinoic-Acid 8μM R07 exp333	1.78
LY2090314 0.003μM R08 exp499	1.88
Oligomycin-A 2μM R00 exp25	1.92
QNZ 0.01μM R05 exp241	2.01
Mubritinib 0.2μM R01 exp48	2.37
Lead acetate 2000μM R08 exp497	2.43
ML-792 0.2μM R08 exp505	2.8
Lead acetate 2000μM R08 exp498 no dilution day6	2.85

Global Fraction of Cell Lines Where Essential: 8/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/14
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sin3-type complex
nuclear speck
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression