SLC38A7
Gene Information
- Official Symbol: SLC38A7
- Official Name: solute carrier family 38 member 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 55238
- UniProt: Q9NVC3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates sodium-dependent transport of amino acids, preferentially L-glutamine. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Trp Tyr perm |
| Aa trans |
GO Terms
| L-methionine transmembrane transporter activity |
| methionine transport |
| L-asparagine transmembrane transporter activity |
| asparagine transport |
| L-leucine transmembrane transporter activity |
| L-histidine transmembrane transporter activity |
| L-histidine transmembrane transport |
| glutamine transport |
| L-serine transport |
| L-glutamine transmembrane transporter activity |
| L-serine transmembrane transporter activity |
| branched-chain amino acid transport |
| L-aspartate transmembrane transporter activity |
| L-alanine transport |
| sulfur amino acid transport |
| L-alanine transmembrane transporter activity |
| serine transport |
| L-aspartate transmembrane transport |
| aromatic amino acid transport |
| alanine transport |
| L-glutamate transmembrane transporter activity |
| L-amino acid transmembrane transporter activity |
| azole transport |
| L-glutamate transmembrane transport |
| C4-dicarboxylate transport |
| amino acid transmembrane transporter activity |
| neutral amino acid transport |
| sulfur compound transport |
| L-alpha-amino acid transmembrane transport |
| acidic amino acid transport |
| L-amino acid transport |
| drug transmembrane transport |
| amino acid transmembrane transport |
| dicarboxylic acid transport |
| amino acid transport |
| organic acid transmembrane transport |
| carboxylic acid transmembrane transport |
| monocarboxylic acid transport |
| drug transport |
| sodium ion transport |
| neurotransmitter transport |
| anion transmembrane transport |
| organic acid transport |
| carboxylic acid transport |
| axon |
| neuronal cell body |
| monovalent inorganic cation transport |
| organic anion transport |
| anion transport |
| cation transmembrane transport |
| metal ion transport |
| cation transport |
| ion transmembrane transport |
| response to drug |
| transmembrane transport |
| ion transport |
| amide transport |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rotenone 2μM R00 exp33 | -1.75 |
| Nocodazole 0.2μM R00 exp24 | -1.72 |
| Selumetinib 20μM R02 exp81 | 1.71 |
| 35°C R06 exp302 | 1.72 |
| Cycloheximide 0.2μM R00 exp15 | 1.87 |
| Vinblastine 0.002μM R01 exp60 | 2.27 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CBWD5 | 0.525 |
| RRM1 | 0.523 |
| TCEB3CL2 | 0.515 |
| CBWD3 | 0.51 |
| SSH2 | 0.508 |
| RNF121 | 0.508 |
| TCEB3CL | 0.497 |
| RRP7A | 0.494 |
| PSMB4 | 0.493 |
| COPG1 | 0.489 |
| TCEB3C | 0.486 |
| DDTL | 0.484 |
| POLA1 | 0.481 |
| CBWD6 | 0.481 |
| ZFAND5 | 0.48 |
| PSMD3 | 0.477 |
| PSMB2 | 0.47 |
| POLR2J3 | 0.467 |
| SUPT6H | 0.466 |
| ATP6V0C | 0.464 |
| TBC1D3G | 0.462 |
| RPL35 | 0.46 |
| NUPL1 | 0.46 |
| AQR | 0.459 |
| CHD4 | 0.458 |
| RPS2 | 0.457 |
| PWP2 | 0.456 |
| BYSL | 0.454 |
| PAN2 | 0.453 |
| TBC1D3H | 0.451 |
| PSMA6 | 0.45 |
| C1QTNF9B | 0.45 |
| PSAP | 0.448 |
| FAM25B | 0.447 |
| MED14 | 0.447 |
| HIST2H3C | 0.446 |
| HIST2H3A | 0.446 |
| SLC6A17 | 0.443 |
| LAD1 | 0.442 |
| RPS7 | 0.441 |
| UPF1 | 0.44 |
| CCNA2 | 0.44 |
| POLR2D | 0.438 |
| GOLGA8J | 0.438 |
| NUP107 | 0.437 |
| MED17 | 0.437 |
| POLR2F | 0.436 |
| TBC1D3C | 0.436 |
| LRR1 | 0.435 |
| TRAIP | 0.434 |
| NUP160 | 0.432 |
| SLC4A1 | 0.432 |
| AATF | 0.432 |
| FCN2 | 0.431 |
| FBL | 0.431 |
| DNTTIP2 | 0.43 |
| RNPC3 | 0.428 |
| SULT1A3 | 0.426 |
| CDC45 | 0.426 |
| SULT1A4 | 0.426 |
| PSMD2 | 0.424 |
| PSMD1 | 0.423 |
| HAP1 | 0.423 |
| SCAF1 | 0.422 |
| RBBP5 | 0.421 |
| NPIPB5 | 0.421 |
| GOLGA6L3 | 0.421 |
| C14orf93 | 0.418 |
| MED12 | 0.418 |
| COPZ1 | 0.417 |
| DTL | 0.416 |
| AHCTF1 | 0.415 |
| PSMD11 | 0.415 |
| RIOK2 | 0.413 |
| RAD21 | 0.413 |
| SYT9 | 0.413 |
| VASN | 0.412 |
| RPL6 | 0.412 |
| EXOSC5 | 0.411 |
| SNIP1 | 0.411 |
| RAD51 | 0.411 |
| PBXIP1 | 0.41 |
| GOLGA8K | 0.409 |
| PSMA7 | 0.409 |
| ORC1 | 0.409 |
| ANKLE2 | 0.409 |
| RPS12 | 0.408 |
| MDM2 | 0.408 |
| GOLGA6L4 | 0.407 |
| SEMA6B | 0.406 |
| POLR2L | 0.406 |
| S1PR4 | 0.404 |
| FAM86B2 | 0.404 |
| RILPL2 | 0.404 |
| PRPF8 | 0.404 |
| TSPY8 | 0.404 |
| PSMD14 | 0.404 |
| PSMC2 | 0.403 |
| TP53TG3D | 0.403 |
| ART5 | 0.403 |
| GOLGA6L1 | 0.403 |
| RRN3 | 0.402 |
| VPS52 | 0.401 |
| CACTIN | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2100
- Expression level (log2 read counts): 5.36
Expression Distribution
SLC38A7 Expression in NALM6 Cells: 5.36
