UXS1

Gene Information

Official Symbol: UXS1
Official Name: UDP-glucuronate decarboxylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 80146
UniProt: Q8NBZ7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
B02 10μM R08 exp453	-4.07
Milciclib 2μM R08 exp502	-3.92
KU-0063794 3.8μM R02 exp71	-3.9
Rapamycin 10μM R00 exp30	-3.76
Rapamycin 1μM R00 exp29	-3.75
Rapamycin 2μM plus FK-506 5μM R07 exp308	-3.68
JQ1 0.8μM R08 exp435	-3.42
5-Azacytidine 2μM R07 exp330	-3.41
Rapamycin 2μM R07 exp306	-3.13
Oligomycin-A 2μM R00 exp25	-3.04
Temozolomide 200μM R04 exp189	-3.03
Radicicol 0.16μM R05 exp242	-2.96
CyclicAMP 200μM R08 exp475	-2.93
Lead acetate 2000μM R08 exp498 no dilution day6	-2.89
Lead acetate 2000μM R08 exp497	-2.79
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.74
All-trans-Retinoic-Acid 40μM R07 exp334	-2.7
Monensin 0.3μM R08 exp507	-2.68
FK-506 30μM R07 exp359	-2.64
LY2090314 0.003μM R08 exp500 no dilution day6	-2.62
Torin1 0.08μM R02 exp82	-2.6
Aphidicolin 0.4μM R08 exp440	-2.58
iCRT14 30μM R08 exp492	-2.54
LY2090314 0.003μM R08 exp499	-2.54
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.5
Zebularine 20μM R07 exp423	-2.5
WYE-354 6μM R02 exp90	-2.46
MK-1775 0.32μM R02 exp75	-2.36
HMS-I2 5μM R06 exp287	-2.27
CB-839 10μM R05 exp224	-2.23
Trimetrexate 0.03μM R08 exp535	-2.18
5-Fluorouracil 20μM R00 exp2	-2.12
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.11
Caffeine 2600μM R08 exp463	-2.08
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.05
Calcium Ionophore 0.4μM R07 exp342	-2.02
Dinaciclib 0.007μM R07 exp355	-1.98
MK2206 4μM R08 exp504	-1.92
ML-792 0.2μM R08 exp505	-1.89
Thimerosal 0.85μM R08 exp529	-1.89
SB203580 25μM R03 exp149	-1.84
Staurosporine 0.02μM R08 exp524	-1.83
Pterostilbene 16μM R02 exp78	-1.81
Resveratrol 16μM R03 exp147	-1.81
BI-D1870 3.15μM R02 exp66	-1.78
AICAR 240μM R03 exp116	-1.75
Amiloride 100μM R08 exp447	-1.75
Docosahexaenoic-acid 50μM R07 exp356	-1.75
Quinacrine 2.5μM R03 exp146	-1.75
Ribavirin 10 to 15μM on day4 R04 exp160	-1.75
Apcin 25μM plus proTAME 2μM R04 exp177	-1.74
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.71
AICAR 240μM R05 exp211	-1.7
I-BRD9 4μM R07 exp365	-1.7
Pyridostatin 4μM R05 exp240	2.15
Bortezomib 0.005μM R00 exp6	2.64

Global Fraction of Cell Lines Where Essential: 75/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	1/28
bone	1/26
breast	9/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	4/16
kidney	3/21
liver	3/20
lung	12/75
lymphocyte	1/16
ovary	2/26
pancreas	6/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 12235
Expression level (log2 read counts): 7.45

Expression Distribution

Gene	Correlation
MED13	0.427
TCF4	0.425

NAD binding 4
RmlD sub bind
3Beta HSD
UXS1 N
Epimerase

UDP-D-xylose biosynthetic process
UDP-glucuronate decarboxylase activity
UDP-D-xylose metabolic process
NAD+ binding
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
Golgi cisterna membrane
protein tetramerization
protein complex oligomerization
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
protein homodimerization activity
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
small molecule metabolic process
protein-containing complex subunit organization