TAF5L
Gene Information
- Official Symbol: TAF5L
- Official Name: TATA-box binding protein associated factor 5 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 27097
- UniProt: O75529
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
Pfam Domains GO Terms
Pfam Domains
| TFIID 90kDa |
| WD40 |
GO Terms
| STAGA complex |
| transcription factor TFTC complex |
| histone H3 acetylation |
| histone acetyltransferase activity |
| cytoplasmic ribonucleoprotein granule |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| protein acetylation |
| protein acylation |
| transcription coactivator activity |
| peptidyl-lysine modification |
| histone modification |
| covalent chromatin modification |
| nuclear speck |
| transcription by RNA polymerase II |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| chromatin organization |
| peptidyl-amino acid modification |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SUPT7L | 0.689 |
| TADA2B | 0.652 |
| TAF6L | 0.626 |
| TADA1 | 0.625 |
| CCDC101 | 0.622 |
| TADA3 | 0.588 |
| MED13 | 0.569 |
| MLLT1 | 0.561 |
| MED13L | 0.535 |
| MED23 | 0.522 |
| KAT2A | 0.521 |
| USP22 | 0.517 |
| BRPF1 | 0.515 |
| MAML1 | 0.509 |
| SUPT20H | 0.479 |
| ZNF592 | 0.476 |
| ID3 | 0.473 |
| FLI1 | 0.467 |
| AFF1 | 0.459 |
| TCEB3 | 0.457 |
| MED16 | 0.455 |
| ATXN7 | 0.452 |
| IRF2BP2 | 0.448 |
| MAPK14 | 0.446 |
| DDX5 | 0.435 |
| RPTOR | 0.433 |
| ATF7IP | 0.432 |
| EHMT2 | 0.425 |
| MAX | 0.419 |
| UBE3A | 0.418 |
| HDAC8 | 0.417 |
| DCAF5 | 0.417 |
| MED25 | 0.414 |
| WDR24 | 0.413 |
| CTDSPL2 | 0.412 |
| SSBP2 | 0.408 |
| ZMIZ1 | 0.408 |
| SETDB1 | 0.406 |
| FBXO11 | 0.405 |
| TLE4 | 0.403 |
| ARIH1 | 0.402 |
| TRIM33 | 0.402 |
| ZNF410 | 0.4 |
| TTI1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 24/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/25 |
| breast | 3/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 2/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 3/15 |
| prostate | 1/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2191
- Expression level (log2 read counts): 5.77
Expression Distribution
TAF5L Expression in NALM6 Cells: 5.77
