UMK57 0.6μM R03 exp107

Potentiates kinesin-13 (MCAK), destabilizes kinetochore-MT attachment, suppresses chromosome mis-segregation

PubChem Name: 5-(4-Methylphenyl)-4-pyrrolidinylthiopheno[2,3-d]pyrimidine
Synonyms: N/A
CAS #: 342595-74-8
PubChem CID: 693939
IUPAC: 5-(4-methylphenyl)-4-pyrrolidin-1-ylthieno[2,3-d]pyrimidine
INCHI Name: InChI=1S/C17H17N3S/c1-12-4-6-13(7-5-12)14-10-21-17-15(14)16(18-11-19-17)20-8-2-3-9-20/h4-7,10-11H,2-3,8-9H2,1H3
INCHI Key: VOAWQTDHSSKEKA-UHFFFAOYSA-N
Molecular Weight: 295.4
Canonical SMILES: CC1=CC=C(C=C1)C2=CSC3=NC=NC(=C23)N4CCCC4
Isomeric SMILES: N/A
Molecular Formula: C17H17N3S

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
5/0	Scores	View	View	View	View	View

Screen	Correlation	Plot
Vincristine 0.0005μM R04 exp190	0.051	View
2-Methoxyestradiol 0.55μM R07 exp310	0.126	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.085	View
BI-D1870 2μM R04 exp162	0.075	View
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	0.069	View
Docosahexaenoic-acid 50μM R07 exp356	0.067	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.067	View
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.067	View
BML-284 0.09μM R08 exp460	0.062	View
Quercetin 20μM R08 exp517	0.062	View
S-trityl-L-cysteine 0.5μM R05 exp243	0.062	View
Mdivi-1 15μM R05 exp217	0.059	View
Epothilone-B 0.0015μM R05 exp231	0.058	View
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	0.056	View
Demecolcine 0.03μM R05 exp228	0.055	View
Cabazitaxel 0.001μM R05 exp223	0.053	View
IU1-C 25μM R04 exp183	0.051	View

GO Term	Fold Change	Genes
ESCRT II complex	592.11	SNF8,VPS25
mitotic sister chromatid segregation	21.61	KNTC1,PRICKLE1,DLGAP5,KIF18A,SPDL1
sister chromatid segregation	21.00	KNTC1,PRICKLE1,DLGAP5,KIF18A,SPDL1
mitotic nuclear division	18.05	KNTC1,PRICKLE1,DLGAP5,KIF18A,SPDL1