COX5A
Gene Information
- Official Symbol: COX5A
- Official Name: cytochrome c oxidase subunit 5A
- Aliases and Previous Symbols: N/A
- Entrez ID: 9377
- UniProt: P20674
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Pfam Domains GO Terms
Pfam Domains
| COX5A |
GO Terms
| mitochondrial respiratory chain complex IV |
| aerobic electron transport chain |
| mitochondrial electron transport, cytochrome c to oxygen |
| cytochrome-c oxidase activity |
| electron transfer activity |
| aerobic respiration |
| mitochondrial ATP synthesis coupled electron transport |
| ATP synthesis coupled electron transport |
| respiratory electron transport chain |
| oxidative phosphorylation |
| proton transmembrane transport |
| cellular respiration |
| electron transport chain |
| ATP metabolic process |
| energy derivation by oxidation of organic compounds |
| mitochondrial inner membrane |
| monovalent inorganic cation transport |
| generation of precursor metabolites and energy |
| inorganic cation transmembrane transport |
| cation transmembrane transport |
| inorganic ion transmembrane transport |
| cation transport |
| ion transmembrane transport |
| oxidation-reduction process |
| transmembrane transport |
| phosphorylation |
| ion transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| C17orf89 | 0.547 |
| YARS2 | 0.54 |
| COX16 | 0.532 |
| MRPS5 | 0.526 |
| HSD17B10 | 0.515 |
| MRPL23 | 0.489 |
| TARS2 | 0.488 |
| MRPS2 | 0.488 |
| RNASEH1 | 0.487 |
| MRPS34 | 0.483 |
| TPK1 | 0.481 |
| MRPS14 | 0.48 |
| DARS2 | 0.477 |
| SARS2 | 0.476 |
| MRPL53 | 0.474 |
| MRPL21 | 0.473 |
| SELRC1 | 0.473 |
| MRPS21 | 0.458 |
| MRPL11 | 0.456 |
| TEFM | 0.454 |
| EARS2 | 0.452 |
| CHCHD4 | 0.449 |
| BCS1L | 0.449 |
| NDUFB5 | 0.447 |
| RPUSD4 | 0.447 |
| GATC | 0.445 |
| COX6C | 0.444 |
| PARS2 | 0.442 |
| KIAA0391 | 0.442 |
| GTPBP10 | 0.441 |
| MRPS16 | 0.439 |
| C10orf2 | 0.439 |
| ELAC2 | 0.439 |
| HARS2 | 0.438 |
| MRPS26 | 0.438 |
| FARS2 | 0.438 |
| MRPS6 | 0.437 |
| UQCRC2 | 0.436 |
| FASTKD5 | 0.434 |
| ATXN10 | 0.434 |
| VARS2 | 0.432 |
| MRPL15 | 0.431 |
| NDUFB11 | 0.43 |
| DAP3 | 0.43 |
| FH | 0.427 |
| THG1L | 0.426 |
| POLG | 0.425 |
| NDUFA3 | 0.423 |
| SLC25A19 | 0.423 |
| QRSL1 | 0.422 |
| MRPL20 | 0.421 |
| NDUFS7 | 0.42 |
| SUPV3L1 | 0.42 |
| SCO2 | 0.419 |
| GFM1 | 0.418 |
| PDSS1 | 0.417 |
| COX17 | 0.417 |
| ADSL | 0.417 |
| RARS2 | 0.416 |
| NDUFB1 | 0.416 |
| RPIA | 0.415 |
| DHRSX | 0.415 |
| NDUFAF7 | 0.413 |
| SLC25A26 | 0.412 |
| MTG2 | 0.411 |
| C12orf65 | 0.405 |
| TMEM242 | 0.405 |
| MRPL12 | 0.404 |
| WBSCR16 | 0.403 |
| ATP5B | 0.402 |
| LSM10 | 0.401 |
| NARS2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 12/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5328
- Expression level (log2 read counts): 7.05
Expression Distribution
COX5A Expression in NALM6 Cells: 7.05
