TIMM13
Gene Information
- Official Symbol: TIMM13
- Official Name: translocase of inner mitochondrial membrane 13
- Aliases and Previous Symbols: N/A
- Entrez ID: 26517
- UniProt: Q9Y5L4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1336
- Expression level (log2 read counts): 5.7
TIMM13 Expression in NALM6 Cells: 5.7
