Citral 50μM R06 exp274

putative ALDH inhibitor, essential oil

PubChem Name: Citral
Synonyms: N/A
CAS #: 5392-40-5
PubChem CID: 638011
IUPAC: (2E)-3,7-dimethylocta-2,6-dienal
INCHI Name: InChI=1S/C10H16O/c1-9(2)5-4-6-10(3)7-8-11/h5,7-8H,4,6H2,1-3H3/b10-7+
INCHI Key: WTEVQBCEXWBHNA-JXMROGBWSA-N
Molecular Weight: 152.23
Canonical SMILES: CC(=CCCC(=CC=O)C)C
Isomeric SMILES: CC(=CCC/C(=C/C=O)/C)C
Molecular Formula: C10H16O

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
4/38	Scores	View	View	View	View	View

Screen	Correlation	Plot
UM0131023 0.05μM R05 exp248	0.112	View
Nifuroxazide 5μM R03 exp102	0.097	View
Deguelin 0.15μM R05 exp209	0.085	View
Ethanol 0.01 R05 exp234	0.079	View
MS023 2μM R03 exp134	0.078	View
Citral 75μM R06 exp275	0.078	View
Trimetrexate 0.03μM R08 exp535	0.077	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.066	View
Hippuristanol 0.12μM R08 exp488	0.064	View
IU1-C 25μM R04 exp183	0.06	View
QNZ 0.01μM R05 exp241	0.06	View
Mubritinib 0.2μM R01 exp48	0.057	View
QNZ 0.01μM R08 exp439	0.055	View
Sulforaphane 9μM R08 exp525	0.053	View
GSK-J4 1-1.25μM to day4 R07 exp363	0.052	View
Hypoxia 5%O2 R04 exp191	0.051	View
Rotenone 0.07μM R08 exp431	0.051	View
AICAR 240μM R03 exp116	0.065	View
Amiloride 100μM R08 exp447	0.056	View
CB-839 10μM R05 exp224	0.052	View

GO Term	Fold Change	Genes
prenyltransferase activity	110.97	PGGT1B,UBIAD1,PDSS1

GO Term	Fold Change	Genes
pyruvate dehydrogenase (NAD+) activity	441.92	PDHA1,DLAT,PDHB,PDHX
pyruvate dehydrogenase [NAD(P)+] activity	331.44	PDHA1,PDHB,PDHX
pyruvate dehydrogenase activity	331.44	PDHA1,DLAT,PDHX
protein histidyl modification to diphthamide	331.44	DPH1,DPH5,DPH2
acetyl-CoA biosynthetic process from pyruvate	276.20	DLAT,PDHB,PDHX
mitochondrial pyruvate dehydrogenase complex	236.74	PDHA1,PDHB,PDHX
peptidyl-histidine modification	236.74	DPH5,DPH2,DPH6
pyruvate dehydrogenase complex	236.74	DLAT,PDHB,PDHX
acetyl-CoA biosynthetic process	169.97	PDHA1,DLAT,PDHB,PDHX
acetyl-CoA metabolic process	78.91	PDHA1,DLAT,PDHB,PDHX
tricarboxylic acid cycle	69.05	PDHA1,MDH1,DLAT,PDHB
thioester biosynthetic process	55.24	PDHA1,DLAT,PDHB,PDHX
acyl-CoA biosynthetic process	55.24	PDHA1,DLAT,PDHB,PDHX
aerobic respiration	23.51	PDHA1,MDH1,DLAT,PDHB,CS,NDUFS4
cellular respiration	19.61	PDHA1,MDH1,DLAT,PDHB,CS,NDUFS4
mitochondrial matrix	10.51	PDHA1,DLAT,PDHB,CS,GPT2,HIBCH,MTHFD2,ECHS1,PDHX
carboxylic acid metabolic process	8.22	PDHA1,MDH1,DLAT,PDHB,CS,GPT2,HIBCH,SLC25A32,MTHFD2,ECHS1,PDHX,SYK
oxoacid metabolic process	8.01	PDHA1,MDH1,DLAT,PDHB,CS,GPT2,HIBCH,SLC25A32,MTHFD2,ECHS1,PDHX,SYK
organic acid metabolic process	7.94	PDHA1,MDH1,DLAT,PDHB,CS,GPT2,HIBCH,SLC25A32,MTHFD2,ECHS1,PDHX,SYK