UNC1999 2μM R03 exp155

Mechanism of Action

Inhibits EZH2 catalytic subunit of PRC2 histone methyltransferase (H3K27me3)

  • Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Technical Notes

Compound References

  • PubChem Name: N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
  • Synonyms: N/A
  • CAS #: 1431612-23-5
  • PubChem CID: 72551585
  • IUPAC: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
  • INCHI Name: InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
  • INCHI Key: DPJNKUOXBZSZAI-UHFFFAOYSA-N
  • Molecular Weight: 569.7
  • Canonical SMILES: CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
  • Isomeric SMILES: N/A
  • Molecular Formula: C33H43N7O2

Compound Supplier

  • Supplier Name: Structural Genomics Consortium
  • Catalog #: N/A
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C33H43N7O2 570.3551; found 570.35617

Dose Response Curve

  • Platform ID: UNC1999
  • Min: -5.1046; Max: 98.9328





IC Concentration (µM)
IC10 N/A
IC20 1.4722
IC30 2.1540
IC40 2.9427
IC50 3.9181
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 03
  • Dose: 2µM
  • Days of incubation: 8
  • Doublings: 7.0
  • Numbers of reads: 10487296

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
2/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1