EPZ-5676 30μM R05 exp233

Mechanism of Action

Inhibits DOT1L lysine methyltransferase (H3K79me2)

  • Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Technical Notes

Compound References

  • PubChem Name: Pinometostat
  • Synonyms: EPZ-5676
  • CAS #: 1380288-87-8
  • PubChem CID: 57345410
  • IUPAC: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol
  • INCHI Name: InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17?,19?,22-,25-,26-,29-/m1/s1
  • INCHI Key: LXFOLMYKSYSZQS-XKHGBIBOSA-N
  • Molecular Weight: 562.7
  • Canonical SMILES: CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
  • Isomeric SMILES: CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
  • Molecular Formula: C30H42N8O3

Compound Supplier

  • Supplier Name: N/A
  • Catalog #: N/A
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C30H42N8O3 563.34526; found 563.34668

Dose Response Curve

  • Platform ID: EPZ-5676
  • Min: -0.8707; Max: 35.7028





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 05
  • Dose: 30µM
  • Days of incubation: 8
  • Doublings: 6.2
  • Numbers of reads: 16438702

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
15/6ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1