Deferoxamine 11μM R07 exp350

Mechanism of Action

Iron chelator, hypoxia mimetic, induces HIF-1‘± accumulation

  • Class / Subclass 1: Environmental Stresses / Metal Chelator
  • Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor

Technical Notes

Compound References

  • PubChem Name: Deferoxamine mesylate
  • Synonyms: Desferrioxamine B mesylate; DFOM; Desferrioxamine B mesylate;DFOM
  • CAS #: 138-14-7
  • PubChem CID: 62881
  • IUPAC: N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid
  • INCHI Name: InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
  • INCHI Key: IDDIJAWJANBQLJ-UHFFFAOYSA-N
  • Molecular Weight: 656.8
  • Canonical SMILES: CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C26H52N6O11S

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: D9533
  • Lot #: BCBV0071

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C25H48N6O8 561.36064; found 561.36098

Dose Response Curve

  • Platform ID: Desferrioxamine
  • Min: -7.4185; Max: 90.5910





IC Concentration (µM)
IC10 N/A
IC20 0.0084
IC30 0.0098
IC40 0.0112
IC50 0.0128
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 11µM
  • Days of incubation: 8
  • Doublings: 1.9
  • Numbers of reads: 18873851

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/31ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1