Lapatinib 5μM R01 exp47

Mechanism of Action

Inhibits EGFR and ErbB2 receptor tyrosine kinases

  • Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Technical Notes

Compound References

  • PubChem Name: Lapatinib Ditosylate
  • Synonyms: GW-572016 ditosylate
  • CAS #: 388082-77-7
  • PubChem CID: 9941095
  • IUPAC: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid
  • INCHI Name: InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)
  • INCHI Key: UWYXLGUQQFPJRI-UHFFFAOYSA-N
  • Molecular Weight: 925.5
  • Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
  • Isomeric SMILES: N/A
  • Molecular Formula: C43H42ClFN4O10S3

Compound Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1028
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C29H26ClFN4O4S 581.14201; found 581.14334

Dose Response Curve

  • Platform ID: LAPATINIB-DITOSYLATE
  • Min: -5.2045; Max: 27.8224





IC Concentration (µM)
IC10 N/A
IC20 6.4969
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 01
  • Dose: 5µM
  • Days of incubation: 8
  • Doublings: 5.2
  • Numbers of reads: 14927766

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
9/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1